急性脑梗死rt-PA溶栓治疗后血浆BNP的变化及临床意义  

Changes and clinical significance of plasma BNP levels after thrombolysis using rt-PA for patients with acute cerebral infarction

作　　者：尹虹祥[1] 陈琦[2] 

机构地区：[1]湖北省新华医院神经内科,武汉430015 [2]湖北省新华医院重症医学科,武汉430015

出　　处：《脑与神经疾病杂志》2015年第5期331-334,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨rt-PA溶栓后脑梗死患者血浆脑钠肽(BNP)水平变化及对复发预测的临床意义。方法对36例急性脑梗死行rt-PA溶栓治疗后观察不同时间血浆BNP水平,比较溶栓再通组和溶栓未通组之间及复发组和未复发组之间的BNP水平的差异。结果溶栓再通组和溶栓未通组之间血浆BNP水平在24h、3d及14d有显著差异,溶栓未通组患者BNP水平较溶栓再通组高,差异有统计学意义(P<0.01);死亡组患者血浆BNP水平较存活组高,差异有统计学意义(P<0.05);复发组与未复发组之间血浆BNP水平差异无统计学意义(P>0.05)。结论溶栓治疗再通后能显著降低急性脑梗死患者血浆BNP水平,血浆BNP可作为脑梗死溶栓治疗再通和死亡风险的预测指标之一;同时对于预测该类患者复发尚无明确预测意义。Objective To explore the changes and recurrence predictive value of plasma levels of brain natriuretic peptide （ BNP ） in patients with acute cerebral infarction （ ACI ） .Methods We observed the level of plasma BNP in 36 patients with ACI in different time after thrombolysis using rt-PA, compared the differences in the levels of BNP between the recanalization group and non-recanalization group , the recurrence group and non-recurrence group .Rseults There were significant differences in the levels of BNP between the recanalization group and non-recanalization group in different times .The plasma BNP level in patients with ACI of non-recanalization group were higher than the recanalization group , the difference was significant （ P〈0.01） .The plasma BNP level in patients with ACI of death group were higher than the survival group , the difference was significant （P〈0.05）.There was no significant difference between the plasma BNP level of recurrence group and non -recurrence group （ P〉0.05 ） . Conclusion Recanalization after thrombolysis could significantly decrease the plasma BNP levels in patients with ACI, the plasma BNP level may become one of the important indexes to predict the recanalization after thrombolysis and death risk .There is no clear significance in predicting recurrence for these patients .

关 键 词：脑梗死 脑钠肽 重组组织型纤溶酶原激活剂 复发 

分 类 号：R743.33[医药卫生—神经病学与精神病学]