河北汉族人群对氧磷酶2 C311S基因多态性的研究  

Genetic polymorphism of paraoxonase 2 C311S among healthy Han population in Hebei province

作　　者：范志亮[1,2] 冯晓娟[3] 李春岩[1] 尹少华[3] 任文博[1,4] 田新英[1] 

机构地区：[1]河北医科大学第二医院神经内科,河北省神经病学重点实验室,石家庄050000 [2]邢台市人民医院神经内三科 [3]邢台市人民医院 [4]天津市第五中心医院

出　　处：《脑与神经疾病杂志》2015年第5期362-365,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨河北汉族人群对氧磷酶2(PON2)C311S基因多态性的分布情况。方法应用聚合酶链式反应-限制性酶切片段长度多态性(PCR-RFLP)方法对209例河北汉族正常人进行PON2 C311S基因多态性分析。结果河北汉族人群PON2 C311S基因多态性符合Hardy-Weinberg遗传平衡定律,具有代表性。PON2 C311S基因CC基因型、CS基因型、SS基因型分别占3.3%、31.1%、65.6%。结论河北汉族人群PON2 C311S基因存在多态性,此人群PON2 C311S基因型分布与海南地区黎族、湖南地区汉族、日本人群一致,而与海南地区汉族、北京地区人群、印度人群、伊朗人群有明显差别。Objective To study the paraoxonase 2 （ PON2） C311S genetic polymorphisms among healthy Han population of Hebei province .Methods Using polymerase chain reaction-restriction fragment length polymorphism （ PCR-RFLP ） to detect the genotypes of PON 2 C311S in 209 healthy Han population of Hebei province .Rseults The genotype distribution of the healthy Hebei Han population was in good agreement with Hardy -Weinberg equilibrium .The PON2 C311S genotype frequency for types of CC ,CS and SS were 3.3%,31.1%,65.6%. Conclusion The results suggest that there exist polymorphisms in PON 2 C311S among healthy Han population of Hebei province .The PON2 C311S gene polymorphism in Hebei healthy Han population is similar to Hainan Li nationality ,Hunan Han population and Japanese population , but significantly different form Hainan Han nationality , Beijing population ,India＇s population and Iran＇s population .

关 键 词：河北汉族 对氧磷酶2C311S 基因 多态性 

分 类 号：R741[医药卫生—神经病学与精神病学]