盐酸舍曲林治疗溃疡性结肠炎伴抑郁的疗效  

Efficacy of sertraline hydrochloride in the treatment of ulcerative colitis complicated with depression

作　　者：周颖婷[1] 吴坚炯[1] 

机构地区：[1]上海交通大学附属第一人民医院消化内科,200080

出　　处：《中华消化杂志》2015年第9期595-598,共4页Chinese Journal of Digestion

摘　　要：目的探讨盐酸舍曲林联合美沙拉秦治疗 UC 伴抑郁患者的疗效。方法纳入2014年3月至2015年3月的轻度 UC 活动期患者80例，抑郁自评量表（SDS）评分为＞53-70分。80例患者分成美沙拉秦联合舍曲林组和美沙拉秦组（对照组），每组40例。两组在纳入研究时和治疗后12周分别进行 SDS 问卷调查和胃肠镜检查，以判定疗效。统计学分析采用卡方检验或 t 检验。结果治疗后12周，美沙拉秦联合舍曲林组和美沙拉秦组的总体有效率分别为75％（30／40）和65％（26／40），差异无统计学意义（P ＞0．05）。治疗前，美沙拉秦联合舍曲林组和美沙拉秦组的溃疡性结肠炎活动指数（UCAI）分别为13．13±4．41和12．41±3．96；治疗后12周，两组的 UCAI 分别为7．29±5．78和8．60±4．56；两组均较治疗前的 UCAI 降低，差异均有统计学意义（t ＝6．1067、5．1893，P 均＜0．01），治疗后两组间 UCAI 差异无统计学意义（P＞0．05）。治疗前，美沙拉秦联合舍曲林组和美沙拉秦组的 SDS 评分分别为（55．98±9．61）和（56．27±8．45）分；治疗后12周，两组 SDS 评分分别为（49．36±4．51）和（52．81±6．11）分；与治疗前相比，治疗后12周美沙拉秦联合舍曲林组和美沙拉秦组的 SDS 评分均下降（t＝3．9440，P＝0．0002；t＝2．0986，P＝0．0391）；治疗后，美沙拉秦联合舍曲林组的 SDS 评分低于美沙拉秦组（t＝2．8732，P＝0．0052）。结论在 UC 常规治疗上加用盐酸舍曲林能明显改善 UC 患者的抑郁情绪，提高患者的生命质量。Objective To investigate the efficacy of sertraline hydrochloride combined with mesalazine in the treatment of patients with ulcerative colitis complicated with depression .Methods From March 2014 to March 2015 ,eighty patients with mild active ulcerative colitis ,self‐rating depression scale （SDS） score between 〉 53 and 70 points ,were enrolled .Eighty patients were divided into sertraline hydrochloride combined with mesalazine group and mesalazine group （control group） ,40 patients in each group .SDS questionnaire and gastrointestinal endoscopy were applied at the beginning of the study and 12 weeks after treatment to evaluate the efficacy .Chi square test or t test was performed for statistical analysis .Results After 12 weeks treatment ,the efficacy of mesalazine combined with sertraline group and mesalazine group was 75% （30/40） and 65% （26/40） , respectively ,and the difference was not statistically significant （ P 〉 0 .05 ） .Before the treatment ,ulcerative colitis activity index （UCAI） of mesalazine combined with sertraline group and mesalazine group was 13 .13 ± 4 .41 and 12 .41 ± 3 .96 , respectively ;12 weeks after treatment ,the UCAI of the two groups were 7 .29 ± 5 .78 and 8 .60 ± 4 .56 , respectively .The UCAI of both the two groups were lower than those before treatment , and the differences were statistically significant （t= 6 .106 7 and 5 .189 3 ,both P 〈 0 .01） .The difference was not statistically significant in UCAI between the two groups after treatment （P 〉 0 .05） .Before treatment ,SDS score of mesalazine combined with sertraline group and mesalazine group was 55 .98 ± 9 .61 and 56 .27 ± 8 .45 , respectively ;12 weeks after treatment ,SDS scores of the two groups were 49 .36 ± 4 .51 and 52 .81 ± 6 .11 ,respectively .Compared with those before treatment , after 12 weeks treatment , SDS scores of mesalazine combined with sertraline group and mesalazine group both decreased （t= 3 .944 0 ,P= 0 .000 2 ;t=2 .098 6 ,P= 0 .039 1） .After treatmen

关 键 词：结肠炎  溃疡性 炎性肠疾病 盐酸舍曲林 抑郁 

分 类 号：R574.62[医药卫生—消化系统]