中缅木莲嫩枝中的桉叶烷型倍半萜  

Eudesmane sesquiterpenes from twigs of Manglietia hookeri

作　　者：其木格[1] 张丰[1] 王文蜀[1,2] 武海波[1,2] 袁昊晨 焦玉国[1] 董旭俊[3] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081 [2]北京市食品环境与健康工程技术研究中心,北京100081 [3]陕西师范大学生命科学学院,陕西西安710091

出　　处：《中国中药杂志》2015年第16期3229-3232,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31200260);高等学校学科创新引智计划项目(B08044);中央民族大学一流大学一流学科建设项目(YLDX01013;2015MDTD08C);中央民族大学2014年校级科研项目(2014MDSHXYQN;Z2014044);中央民族大学本科生研究训练计划项目(GCCX2014110015;GCCX2015110038)

摘　　要：利用硅胶、sephadex LH-20及制备薄层色谱等方法,对中缅木莲Manglietia hookeri嫩枝的丙酮提取物进行化学成分的研究。利用核磁共振波谱(NMR)、质谱(MS)及化合物的理化性质,对化合物的结构进行了鉴定。从中缅木莲中分离得到了6个桉叶烷型倍半萜类化合物,它们的结构鉴定分别为柳杉醇(1),β-桉醇(2),(-)-10-epi-5β-hydroxy-β-eudesmol(3),epicarrisone(4),6-羟基-桉烷-4(14)-烯(5)和gynurenol(6)。6个化合物均为首次从该植物中分离得到,并首次报道了化合物3的碳谱数据。Chemical constituents from the acetone extract of twigs of Manglietia hookeri were isolated and purified by various column chromatographic methods over silica gel and sephadex LH-20, and preparative TLC. The structures of these compounds were identified on the basis of physicochemical properties and spectral analysis, including NMR and MS spectra. Six eudesmane sesquiterpenes were obtained and their structures were identified as trans-eudesmane-4,11-diol（ 1 ）, β-eudesmol （2）, （ - ） -10-epi-5 β-hydroxy-β-eudesmol （3）, epi-carrisone（4）, 6-hydroxy-eudesm-4（14）-ene（5） and gynurenol（6）. All the compounds were isolated from this plant for the first time. Furthermore, the 13 C-NMR data of compound 3 were reported for the first time.

关 键 词：木莲属 中缅木莲 桉叶烷 倍半萜 (-)-10-epi-5β-hydroxy-β-eudesmol 

分 类 号：R284[医药卫生—中药学]