子宫肌瘤发生风险关系的研究  

Study on the risk factors of uterine fibroids

作　　者：徐桂强[1] 吴静[1] 申丽君[1] 张艳梅[1] 宋璐璐[1] 杨斯怡 田耀华[1] 杨汉东[1] 王友洁[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院,湖北武汉430030

出　　处：《中国妇幼保健》2015年第29期5019-5023,共5页Maternal and Child Health Care of China

基　　金：国家自然科学基金〔81273083〕;华中科技大学自主创新基金〔2014TS051〕

摘　　要：目的探讨产次及其他因素与子宫肌瘤发生之间的关系。方法研究数据来自东风一同济退休职工队列研究。选取队列中有完整资料的14280名中老年女性为研究对象，采用多因素Logistic回归模型分析产次与子宫肌瘤发生的关系。结果研究对象中子宫肌瘤患病率为15．7％（2239／14280）。多因素Logistic回归分析结果显示，与产次为1个的女性相比，产次为2次、3次、4次及以上的女性罹患子宫肌瘤的危险度逐渐降低，OR值分别为0．793（95％CI：0．702—0．897）、0，666（95％CI：0．558—0．794）和0．543（95％CI：0．422～0．700）。子宫肌瘤的患病危险性随着产次的增加而减少。结论多产次可以降低子宫肌瘤发生的风险，在中国女性中多产次可能是子宫肌瘤的保护因素，该研究结果提示产次少的妇女应注意预防子宫肌瘤的发生。Objective To explore the relationships between parity and other factors and occurrence of uterine fibroids. Methods The research data was from the Dongfeng-Tongji retired ex-employees cohort study, 14 280 middle and old-aged women with intact informa- tion were selected as research subjects from the cohort. Multivariate Logistic regression model was used to analyze the relationship between parity and occurrence of uterine fibroids. Results The prevalence rate of uterine fibroids was 15.7% （2 239/14 280） . Multivariate Logis- tic regression analysis showed that compared with the women with birth history for one time, the risk ratios of uterine fibroids in the women with birth history for two, three, and four or more than four times decreased gradually, OR values were 0. 793 （95% CI： 0. 702-0. 897）, 0. 666 （95% CI： 0. 558-0. 794）, and 0. 543 （95% CI： O. 422-0. 700） . The risk of uterine fibroids decreased with the increase of parity. Conclusion Multiparity can reduce the risk of uterine fibroids, which may be the protective factor of uterine fibroids, the findings suggested that the occurrence of uterine fibroids should be paid attention to among the women with less parity.

关 键 词：子宫肌瘤 产次 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]