FOXO的调控与肿瘤治疗关系的研究进展  

Research progress on the relationship between FOXO regulation and cancer treatment

作　　者：杨明建[1] 于振涛[1] 

机构地区：[1]天津医科大学肿瘤医院食管肿瘤科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2015年第18期926-929,共4页Chinese Journal of Clinical Oncology

基　　金：天津市高等学校科技发展基金计划项目(编号:20130121)资助~~

摘　　要：叉头框(forkhead box,Fox)基因家族即Forkhead是以果蝇中发现的叉头基因来命名的,广泛存在于从酵母到哺乳类的真核生物中,其编码产物FOXO蛋白家族在细胞代谢、增殖、氧化应激和凋亡等方面发挥重要作用。细胞存活相关的信号通路的激活如PI3K/AKT或RAS/ERK等,通过磷酸化FOXO不同位点调节FOXO核定位或降解。FOXO因子作为肿瘤抑制因子在多种肿瘤中起重要作用,肿瘤与FOXO之间的关系已成为研究的热点。增加或恢复FOXO活性的药物治疗有望成为与化疗或放疗结合的潜在治疗策略。本文就FOXO的调控和作为分子靶向治疗靶点的最新研究进展进行综述。The FOXO gene, which is a member of the Forkhead box （Fox） gene family, is found in drosophila and is widespread in the eukaryotes of many organisms, including yeast and mammals. This gene transcripts the FOXO protein family, which has impor-tant roles in metabolism, cellular proliferation, stress resistance, and apoptosis. Activation of cell survival pathways, such as phos-phoinositide-3-kinase/AKT or RAS/mitogen-activated protein kinase, phosphorylates FOXOs at different sites, thus regulating the nu-clear localization or degradation of FOXOs. A growing number of evidence indicates that FOXO acts as a tumor suppressor in a wide variety of tumors. Scientists have focused on the correlation between tumors and FOXO. In combination with other chemo-or radiother-apy treatments, drugs designed to increase or restore FOXO activity may constitute a potential strategy in cancer treatment. This review summarizes details on the regulation of FOXO and the latest research progress of FOXO as a molecule therapeutic target.

关 键 词：FOXO 肿瘤治疗 凋亡 增殖 自噬 

分 类 号：R730.5[医药卫生—肿瘤]