碘酊烧灼联合氟康唑和二性霉素B治疗真菌性角膜炎的效果观察  

Effect observation of iodine burning combined with fluconazole and amphotericin B treating fungal keratitis

作　　者：徐雅萍 张敏 陈欢 董科 

机构地区：[1]江西省德兴市人民医院五官科,江西德兴334200

出　　处：《中国当代医药》2015年第27期110-111,114,共3页China Modern Medicine

摘　　要：目的 探讨碘酊烧灼联合氟康唑和二性霉素B治疗真菌性角膜炎的临床效果。方法 选取2014年3~10月我院收治的真菌性角膜炎患者84例,随机分为三联组和二联组,二联组采用氟康唑联合二性霉素B治疗,三联组采用碘酊烧灼联合氟康唑和二性霉素B治疗,比较两组患者的症状消失时间和治疗效果。结果 三联组患者角膜溃疡、前房脓肿、异物感、畏光流泪的临床症状消失时间均短于二联组[（20.5±2.6）dvs（24.8±2.9）d,（18.8±2.4）dvs（23.4±2.7）d,（15.4±2.0）dvs（17.8±2.2）d,（21.2±2.8）d vs（26.6±2.9）d]（P〈0.05）。三联组的治疗效果显著优于二联组（总有效率：97.62%vs 83.33%）（P〈0.05）。结论 碘酊烧灼联合氟康唑和二性霉素B治疗真菌性角膜炎可缩短患者的症状消失时间,提高治疗效果。Objective To evaluate the clinical effect of iodine burning combined with fluconazole and amphotericin B treating fungal keratitis. Methods 84 cases with fungal keratitis treated in our hospital from March to October 2014 were selected and they were randomly divided into triple group and bivalent group,bivalent group was given fluconazole combined with amphotericin B,and triple group was given iodine burning combined with fluconazole and amphotericin B.The disappearing time of symptom and treatment effect in patients between two groups was compared respectively. Results The disappearing time of clinical symptom of corneal ulcer,anterior abscess,foreign body sensation,photophobia, tearing in bivalent group was shorter than that of bivalent group respectively [（20.5±2.6）dvs（24.8±2.9）d,（18.8±2.4）dvs（23.4±2.7）d,（15.4±2.0）dvs（17.8±2.2）d,（21.2±2.8）d vs（26.6±2.9）d]（P〈0.05）.Treatment effect of triple group was obviously better than that of bivatent group （the total effective rate：97.62% vs 83.33%） （P〈0.05）. Conclusion Iodine burning combined with fluconazole and amphotericin B treating fungal keratitis may shorten the disappearing time of symp- tom in patients and improve the treatment effect.

关 键 词：碘酊烧灼 氟康唑 二性霉素B 真菌 角膜炎 

分 类 号：R772.21[医药卫生—眼科]