婴儿先天性白内障摘出术后早期中央角膜厚度变化与眼压的相关性研究  

Central corneal thickness changes of infantal congenital cataracts and its correlation with intraocular pressure following extraction surgery

作　　者：王明玥[1] 肖伟[1] 濮伟[1] 赵岱新[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,辽宁省沈阳市110004

出　　处：《眼科新进展》2015年第10期931-934,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:30973276)~~

摘　　要：目的测量并观察生后12个月以内行先天性白内障摘出术患儿术后术眼中央角膜厚度(central corneal thickness,CCT)及眼压(intralocular pressure,IOP)的变化。方法选取26例(49眼)生后12个月内行白内障摘出术的先天性白内障患儿为观察组,按行手术时月龄分为三组:1组:月龄≤3个月,2组:3个月<月龄≤6个月;3组:6个月<月龄≤12个月。分别在术前、术后1个月、3个月、6个月时测量术眼CCT与IOP。另选取与各观察组最后一次随访时的患儿年龄与性别相匹配的相对正常眼婴幼儿作为对照组。结果观察组术后1个月、3个月、6个月的CCT为(578.39±47.79)μm、(581.34±51.54)μm、(588.29±49.90)μm,均显著大于术前(563.56±37.14)μm及对照组(534.96±40.34)μm(均为P<0.05)。观察组术前、术后1个月、3个月、6个月IOP测量值间差异无统计学意义(P>0.05),观察组术后6个月IOP测量值大于对照组(P<0.05)。观察组术后6个月CCT与IOP线性相关(r=0.538,P=0.004)。结论婴儿先天性白内障摘出术后早期的CCT显著大于正常同龄婴儿,且与IOP线性相关。Objcetive To investigate the changes of central corneal thickness （CCT） and intraocular pressure （IOP） following congenital cataract extraction in in- fants within postnatal 12 months. Methods Follow-up investigation were studied in 26 cases（49 eyes） of infants with congenital cataract extraction operation within post- natal 12 months. According to the months,the infants with congenital cataract were di- vided into three groups： ≤3 months group,3 -6 months group ,6 - 12 months group. IOP and CCT in the operated eyes at pre-operation and postoperative 1 month,5 months and 6 months were detected. The relative normal infants with the age and gender matched with the infants in each observation group at the final follow-up were chosen as the control group. Results CCT in the observation group at postoperative 1 month, 3 months and 6 months were （ 578.39 ± 47.79 ）μm, （ 581. 34 ± 51.54 ） μm and （ 588.29 ± 49. 90） μm, respectively, which were higher than the pre-operation （ 563.56 ± 37.14 ） μm and control group （534.96 ± 40.34） μm（ all P 〈 0.05 ）. There was no statistical difference in IOP among pre-operation,postoperative 1 month,3 months and 6 months（P〉0.05）, and IOP in the observation group at postoperative 6 months was higher than that in the control group（P 〈 0.05 ）. There was a linear correlation between CCT and IOP in the observation group （ r = 0.538 ,P = 0. 004）. Conel±ion CCT at the early postoperative time following cataract extraction is obviously higher than the same aged normal inrants,and CCT is increased in eyes undergoing congenital cataract surgery when the surgery is performed at an early age. CCT is linear correlated with IOP.

关 键 词：先天性白内障 中央角膜厚度 眼压 白内障摘出术 

分 类 号：R779.66[医药卫生—眼科]