波前像差在屈光参差性弱视光学质量评估中的应用  

Application of wavefront aberration in optical quality assessment for anisometropic amblyopia

作　　者：赵武校[1] 蓝方方[1] 李志超[1] 甘露[1] 刘伟民[1] 

机构地区：[1]广西壮族自治区人民医院视光科广西视光中心,广西壮族自治区南宁市530021

出　　处：《眼科新进展》2015年第10期939-944,共6页Recent Advances in Ophthalmology

基　　金：广西壮族自治区卫生厅资助项目(编号:桂卫Z2013336);广西壮族自治区人民医院青年基金项目~~

摘　　要：目的 探讨屈光参差性弱视双眼间的波前像差差异以及临床特点。方法 选取53例屈光参差性弱视患者,年龄9∽40岁,其中男31例,女22例,纳入本横断面研究。所有患者均接受Wave Scan波前像差检查,弱视眼与对侧眼之间的波前像差差异采用配对t检验;波前像差参数值、等效离焦度、最佳矫正视力,以及年龄之间的关系采用相关分析。然后将中度弱视患者按照年龄分为成年弱视组和儿童弱视组,分析这两组的临床特点。结果 经配对t检验显示,53例患者的弱视眼与对侧眼在最佳矫正视力、等效离焦度、总像差、总高阶像差、三叶草像差、三阶像差均方根值等指标上差异均有统计学意义（均为P〈0.05）。成年弱视组与儿童弱视组内均未发现年龄与高阶像差参数之间存在相关性。成年弱视组弱视眼与对侧眼之间在总像差（P=0.000）、三叶草像差（P=0.047）和三阶像差均方根值（P=0.032）上差异均有统计学意义（均为P〈0.05）;儿童弱视组弱视眼与对侧眼之间在总像差（P=0.000）、球差（P=0.008）和四阶像差均方根值（P=0.032）上差异均有统计学意义（均为P〈0.05）。两个年龄组内的相关回归分析显示,在成年弱视组,等效离焦度与总像差有相关性（P〈0.01）,最佳矫正视力与总像差、球差均有相关性（均为P〈0.05）;且等效离焦度与总像差的回归方程为y=3.343＋0.942x（F=40.830、P=0.000、R2=0.671）,最佳矫正视力与总像差的回归方程为y=0.321＋0.017x（F=5.058、P=0.036、R2=0.202）。在儿童弱视组,等效离焦度与总像差、总高阶像差均有相关性（均为P〈0.05）,最佳矫正视力与五阶像差均方根值存在相关性（P〈0.01）;等效离焦度与总像差的回归方程为y=1.529＋1.176x（F=17.090、P=0.001、R2=0.501）,最佳矫正视力与五阶像差均方根值的回归方程为y=0.006＋0.143x（F=10.851、P=0.004、R2=0.390）。结论 除最�Objective To investigate the differences of wavefront aberrations and clinical profile in auisometropic amblyopia. Methods Fifty-three patients with anisometropic amblyopia aged 9 to 40 years old ,31 males and 22 females ,were enrolled in our cross-sectional study. All patients were examined by WaveScan Wavefront system. Paired t-test was used to compare the differences of wavefront aberration parame- ters between amblyopic and fellow eyes, and correlation analysis were used among age, best corrected visual acuity（BCVA） ,defocus equivalent（DE） ,and wavefront aberration parameters. Then moderate amblyopic patients were selected and divided into children and adults groups according to their age, and their interocuiar differences and relationships were also analyzed within groups. Results Significant differences were found in BCVA, DE, total aberration, total higher order root mean square （ RMS）, trefoil, and third order RMS between amblyopic and fellow eyes of the whole anisometropic amblyopes. But no relationship was noted between age and higher order aberration parameters in both eyes of anisometropic amblyopia. When moderate amblyopia split into adults and children groups, significant differences in total aberration （ P = 0. 000 ）, trefoil （ P = 0. 047） ,and 3rd RMS（P =0. 032） were found between amblyopic and fellow eyes of a- dults group. By contrast, significant differences in total aberration（P = 0.000 ）, spherical aberration （P = 0.008 ）, and 4th RMS （ P = 0.032 ） were observed between amblyopic and fellow eyes of children group. FhLrthermore, in adults group, statistically significant asso- ciations between DE and total aberration （P 〈 0.01 ）, between BCVA and total aberra- tion, and spherical aberration（ both P 〈 0.05 ） were noted in amblyopic eye, and the line- ar regression equation between DE and total aberration was y = 3. 343 ＋ 0. 942x （F = 40. 830,P = 0. 000,R2 = 0. 571 ） ,between BCVA and total aberration was y = 0. 32l ＋ 0. 017x（F = 5. 058

关 键 词：屈光参差性弱视 波前像差 最佳矫正视力 等效离焦度 

分 类 号：R777.44[医药卫生—眼科]