固体碱催化合成3-甲胺基-1,2-丙二醇  

Synthesis of 3-Methylamino-1,2-propandiol Catalyzed by Solid Base Catalyst

作　　者：张恭孝[1] 杨荣华[1] 陈玉新[1] 孟宪锋[1] 

机构地区：[1]泰山医学院化工学院,山东泰安271016

出　　处：《精细化工》2015年第10期1175-1180,共6页Fine Chemicals

基　　金：山东省自然科学基金(ZR2014BL010)~~

摘　　要：以3-氯-1,2-丙二醇和一甲胺为原料,选用载有三乙胺的固体碱作催化剂合成3-甲胺基-1,2-丙二醇。采用正交实验和单因素分析探讨了反应的影响因素,得到最佳工艺条件为:3-氯-1,2-丙二醇与一甲胺(折算成100%)物质的量之比为1∶8,反应温度60℃,反应压力0.20 MPa,反应时间3.5 h,在该条件下3-甲胺基-1,2-丙二醇合成收率可达91.9%。通过元素分析、气相色谱、红外光谱对产物进行表征,结果证实得到了目标产物,且纯度可达99.5%以上。3-Methylamino-1,2-propandiol was synthesized with solid-base carrying triethylamine as catalyst and 3-chloro-1,2-propanediol and methylamine as raw materials. The influence factors on this reaction were investigated by orthogonal test and single factor analysis. It was indicated that the best process conditions for this reaction were as follows： the mole ratio of 3-chloro-1,2-propanediol to methylamine（ converted into 100%） was 1∶8,the reaction temperature was 60 ℃,the reaction pressure was 0. 20 MPa,and the reaction time was 3. 5 h. Under the optimum reaction conditions,the synthesis yield of 3-methylamino-1,2-propandiol was 91. 9%. The product was characterized by means of elemental analysis,gas chromatography and infrared spectrum method,and the product purity was99. 5% at least.

关 键 词：固体碱 3-氯-1 2-丙二醇 3-甲胺基-1 2-丙二醇 胺化反应 精细化工中间体 

分 类 号：TQ223.3[化学工程—有机化工]