龙血竭对Lewis肺癌小鼠放疗模型的辅助治疗效果  

Effect of Resina Draconis on the efficacy of radiotherapy to Lewis lung carcinoma mice

作　　者：戴荣继[1] 余博文[1] 王冉[1] 代胜平[1] 陈艳 林凡凯[1] 孟薇薇[1] 邓玉林[1] 

机构地区：[1]北京理工大学生命学院,北京100081 [2]北京理工亘元科技有限公司,北京100081

出　　处：《科技导报》2015年第18期68-71,共4页Science & Technology Review

基　　金：国家重大仪器专项(2012YQ040140)

摘　　要：龙血竭具有一定的防辐射作用。通过在C57/BL小鼠右前腋窝皮下注射Lewis肺癌细胞,对小鼠进行4 Gy全身一次性γ辐射建立Lewis肺癌小鼠放疗模型,并给予小鼠龙血竭,进行肿瘤生长、肿瘤转移和血象变化检测,研究了龙血竭对Lewis肺癌小鼠放疗模型的血象及肿瘤生长的辅助治疗效果。实验发现,龙血竭不会促进放疗Lewis肺癌小鼠的肿瘤生长和转移,并能够有效保护放疗Lewis肺癌小鼠的血小板。研究表明,龙血竭应用于肿瘤的放射治疗可以对辐射引起机体的血象损伤起到保护作用。It is confirmed that the Resina Draconis has an anti-radiation effect. In this paper, the Lewis lung carcinoma mice model is established on the C57/BL mice by injecting the Lewis lung carcinoma cell in the right auxiliary of the mice. The mice are irradiated by the 4 Gy 5,-radiation and treated with the Resina Draconis. Then the tumor growth and metastasis as well as the blood index are examined to study the effect of the Resina Draconis on the efficacy of radiotherapy for the Lewis lung carcinoma mice. The results show that the Resina Draconis has no obvious effect on the tumor weight, the tumor volume and the tumor metastasis. But the Resina Draconis has a significant protective effect on the blood platelet for the radiotherapy-treated Lewis lung carcinoma mice. Therefore, it might be concluded that the Resiua Draconis can be used for the radiotherapy treatment of cancer.

关 键 词：龙血竭 放疗 LEWIS肺癌小鼠 放疗辅助用药 

分 类 号：R734.2[医药卫生—肿瘤] R-332[医药卫生—临床医学]