微小RNA在椎间盘退变中的研究进展  

RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION

作　　者：李新华[1] 崔健[1] 孙贵新[1] 谭军[1] 李立钧[1] 

机构地区：[1]同济大学附属东方医院脊柱外科,上海200092

出　　处：《中国修复重建外科杂志》2015年第10期1312-1316,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81171700);上海市浦东新区学科带头人计划资助项目(PWRd-2011-02)~~

摘　　要：目的总结微小RNA(micro RNA)在椎间盘退变中的研究进展,分析其在椎间盘退变中的研究方向和临床应用潜能。方法广泛查阅国内外有关micro RNA在椎间盘退变中作用的相关文献并进行综述。结果micro RNA是通过对基因表达进行调控,从而影响椎间盘细胞的增殖与凋亡、增加退变椎间盘组织的炎性介质和蛋白酶等方式在椎间盘退变中发挥重要作用。结论 micro RNA是椎间盘退变领域的研究新热点,对micro RNA的研究将有助于明确椎间盘退变的发病机制,同时为椎间盘退变疾病的诊断与治疗提供了新思路。Objective To comprehensively analyze the relationship between microRNAs and intervertebral disc degeneration at home and abroad. Methods The literature about the relationship between microRNAs and intervertebral disc degeneration was reviewed and analyzed. Results MicroRNA can lead to intervertebral disc degeneration by regulating the gene expression, thus influencing the cell’s apoptosis and proliferation, increasing of the production of inflammatory mediator and protease, which play important roles in intervertebral disc degeneration. Conclusion MicroRNA is a research focus in the field of intervertebral disc degeneration. Further research of the relationship between microRNAs and intervertebral disc degeneration will help to identify the pathogenesis of intervertebral disc degeneration and furnish the new ideal for the diagnosis and treatment of intervertebral disc degeneration.

关 键 词：微小RNA 椎间盘退变 基因诊断 基因治疗 

分 类 号：R681.5[医药卫生—骨科学]