炎症性肠病中细胞因子对肠上皮紧密连接的影响及针灸效应机制研究概况  

Research Overview on Cytokines on Intestinal Epithelial Tight Junction in Inflammatory Bowel Diseases and the Effect Mechanism of Acupuncture and Moxibustion

作　　者：商海霞[1] 郑寒丹 吴焕淦[2] 季亚婕[1,2] 施茵[2] 

机构地区：[1]上海中医药大学,上海201203 [2]上海市针灸经络研究所,上海200030

出　　处：《中华中医药学刊》2015年第10期2344-2347,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273844;81473757);国家重点基础研究发展计划(973计划)项目(2015CB554500)

摘　　要：肠上皮屏障通透性的改变是炎症性肠病发病的首要因素。TNF-α、IFN-γ、IL-1β等促炎细胞因子和IL-4、IL-10等抗炎细胞因子通过影响肠上皮紧密连接来间接调控肠上皮屏障,进而介导炎症性肠病的发生与发展。近年来,针灸治疗炎症性肠病疗效较好,而其主要效应机制之一是通过调节细胞因子来降低肠上皮屏障通透性、改善其肠上皮屏障功能。Altered intestinal epithelial barrier permeability is the primary factor underlying the pathogenesis of Inflammatory Bowel Disease （IBD）. Pro- inflammatory cytokines including TNF-α, IFN-γ, IL- 1β and anti- inflammatory cytokines such as IL - 4, IL - 10 influence the permeability of intestinal epithelial barrier by regulating the function of the tight junction, thereby mediating the occurrence and progression of 1BD. In recent years, acupuncture and moxibustion has presented promised efficiency in treating IBD. And one of the mechanisms of these therapies is restoring intestinal epithelial barrier function through the regulation of？ cytokines.

关 键 词：炎症性肠病 细胞因子 肠上皮紧密连接 针灸效应 

分 类 号：R574[医药卫生—消化系统]