养正消积胶囊配合介入化疗或放疗治疗原发性肝癌有效性和安全性的Meta分析  

Meta-analysis of Yangzhengxiaoji capsule combined with interventional chemotherapy or radiotherapy in the treatment of primary hepatocellular carcinoma

作　　者：杨立波[1] 韩硕龙[1] 高学东[1] 

机构地区：[1]河北以岭医院/河北以岭医院研究院,石家庄050035

出　　处：《疑难病杂志》2015年第10期1074-1077,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的系统评价养正消积胶囊配合介入化疗或放疗治疗原发性肝癌的临床疗效及安全性。方法计算机检索PubMed、EM-base、中国知网、万方数据、中国博士学位论文全文数据库、中国优秀硕士学位论文全文数据,全面收集养正消积胶囊治疗原发性肝癌的所有随机对照试验。采用RevMan 5.3软件进行Meta分析。结果共纳入8个文献,共1 868例患者。Meta分析结果显示：试验组与对照组相比,其实体肿瘤近期疗效有效率（OR=1.36,95%CI 1.12∽1.65,P=0.002）、生活质量（OR=1.96,95%CI 1.52∽2.54,P〈0.01）及体质量升高率（OR=1.97,95%CI1.45∽2.66,P〈0.01）的差异均有统计学意义;其血白细胞下降（OR=0.35,95%CI 0.25∽0.50,P〈0.01）、血小板下降（OR=0.39,95%CI 0.28∽0.54,P〈0.01）及恶心呕吐发生率（OR=0.30,95%CI 0.21∽0.41,P〈0.01）的差异均有统计学意义。结论养正消积胶囊配合介入化疗或放疗治疗原发性肝癌,能缩小肿瘤,改善生活质量、提供体质量,减轻放化疗的不良反应。Objective To systemic evaluate the clinical efficacy and safety of Yangzhengxiaoji capsule combined with interventional chemotherapy or radiotherapy in the treatment of primary liver cancer .Methods Computer retrieval PubMed , EM and base, CNKI, Wanfang Data, Chinese doctoral dissertations full text database , China outstanding master＇s Degree Dis-sertation Full-text data, comprehensive collected all randomized controlled trials of Yangzhengxiaoji capsule in the treatment of primary hepatocellular carcinoma （HCC）.Meta-analysis was performed using RevMan 5.3 software.Results A total of 8 lit-eratures were included , and a total of 1 868 patients were included .Meta-analysis results showed：compared the experimental group and the control group , recent effect of treating solid tumor （OR=1.36, 95%CI 1.12-1.65, P =0.002）, quality of life （OR=1.96, 95%CI 1.52-2.54, P 〈0.01） and body mass increased rate （OR=1.97, 95%CI 1.45-2.66, P 〈0.01） were significant different;the white blood cells decreased rate （OR=0.35, 95%CI 0.25-0.50, P 〈0.01）, platelet decreased rate （OR=0.39, 95%CI 0.28-0.54, P 〈0.01） and nausea vomiting occurred rate （OR=0.30, 95%CI 0.21-0.41, P 〈0.01）’s differences were different statistical significance .Conclusion Yangzhengxiaoji capsule combined with interventional chemotherapy or radiotherapy in the treatment of primary hepatocellular carcinoma can decrease tumor size , im-prove life quality , raise the quality of donor and reduce the adverse effects of radiotherapy and chemotherapy .

关 键 词：养正消积胶囊 原发性肝癌 META分析 系统评价 随机对照试验 

分 类 号：R735.7[医药卫生—肿瘤]