胺碘酮联合阿托伐他汀对兔心功能的实验研究  

Study of the effect of amiodarone combined with atorvastatin intervention on rabbit cardiac functional properties

作　　者：来欣[1] 王晞[1] 党松[1] 段慧楠[1] 王鑫[1] 胡娟[1] 刘自强[1] 

机构地区：[1]武汉大学人民医院心血管内科,湖北武汉430060

出　　处：《海南医学》2015年第17期2497-2499,共3页Hainan Medical Journal

基　　金：国家重点基础研究发展计划(973计划)(编号:2012CB518604);湖北省自然科学基金(编号:2013CFA117;2013CKB005)

摘　　要：目的观察胺碘酮+阿托伐他汀对日本大耳兔心肌梗死(心梗)模型的心功能的影响,以探讨其治疗心梗后抗心律失常的机制。方法将24只日本大耳兔随机分为假手术对照组、心肌梗死对照组(心梗对照组)、心肌梗死胺碘酮+阿托伐他汀组(心梗药物干预组),以前降支动脉结扎术建立心梗模型,心梗药物干预组于结扎术后第1天开始分别以50 mg·kg-1·d-1(胺碘酮)+3 mg·kg-1·d-1(阿托伐他汀)灌胃8周。8周后,行超声心动图检测。结果与假手术对照组比较,心梗对照组左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)均增大,左心室短轴缩短率(LVFS)、左心室射血分数(LVEF)均减少,差异均有统计学意义(P<0.05);与心梗对照组比较,心梗药物干预组的LVESD、LVEDD、LVEDV、LVESV均减少,LVFS、LVEF均增大,差异均有统计学意义(P<0.05)。结论胺碘酮联合阿托伐他汀可以有效改善心肌梗死后心脏的功能,通过改善心功能发挥抗心梗后心律失常的作用。Objective To observe the effect of amiodarone combining atorvastatin on cardiac functional properties in Japanese rabbits with myocardial infarction （MI） model, in order to explore the arrhythmia mechanism of treatment of post MI. Methods Twenty-four Japanese rabbits were randomly divided into sham operation group, myocardial infarction control group, myocardial infarction drugs intervention group （amiodarone combined with atorv-astatin）. Myocardial infarction model was established via anterior descending coronary artery ligation. The myocardial infarction drugs intervention group was given amiodarone （50 mg·kg^-1·d^-1） and atorvastatin （3 mg·kg^-1·d^-1） eight weeks after ligation. After eight weeks, echocardiography testing was performed. Results Compared to the sham control group, the left ventricular end-systolic diameter （LVESD）, left ventricular end-diastolic diameter （LVEDD）, left ventricular end-diastolic volume （LVEDV） and left ventricular end-systolic volume （LVESV） in myocardial infarc-tion control group increased significantly （P〈0.05）, while left ventricular fractional shortening （LVFS） and left ventric-ular ejection fraction （LVEF） reduced significantly （P〈0.05）. Compared to myocardial infarction control group, the LVESD, LVEDD, LVEDV and LVESV in myocardial infarction drugs intervention group significantly decreased （P〈0.05）, while LVFS and LVEF significantly increased （P〈0.05）. Conclusion Amiodarone combined with atorvastatin could improve cardiac function after myocardial infarction, which play an important role in anti-arrhythmia after myo-cardial infarction.

关 键 词：胺碘酮 阿托伐他汀 心肌梗死 心功能 兔 

分 类 号：R-332[医药卫生]