岭南地区溃疡性结肠炎的中医证候与内镜分型及黏膜组织分期的相关性研究  

Relationship between TCM syndrome of ulcerative colitis in Lingnan area and endoscopic classification and mucosal tissue staging

作　　者：黄新贻 李琛琛[2] 杨永和[1] 吴仕文[1] 

机构地区：[1]海南省中医院内科,海南海口570203 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《海南医学》2015年第17期2519-2521,共3页Hainan Medical Journal

基　　金：国家中医药管理局课题基金(编号:2007BAI10B01-070)

摘　　要：目的研究岭南地区溃疡性结肠炎的中医证候分别与结肠镜像分型、黏膜组织学分期的相关性,为中医辨证提供客观依据。方法收集岭南地区溃疡性结肠炎患者124例,统计不同证候所占比例,分析中医证型与结肠镜像分型、黏膜组织学分期各自的相关性。结果岭南地区溃疡性结肠炎临床以大肠湿热、脾虚湿热、脾胃气虚三类证型多见。结肠镜像分型Ⅰ型以大肠湿热证多见,脾虚湿热证、脾胃气虚证少见(P<0.05);Ⅱ型三证出现的概率相当;Ⅲ型以脾胃气虚证、脾虚湿热证多见,大肠湿热证少见(P<0.05)。黏膜组织学分期活动期多见于大肠湿热证,与脾虚湿热证、脾胃气虚证比较,差异均有统计学意义(P<0.05);缓解期多见于脾虚湿热证、脾胃气虚证,与大肠湿热证比较,差异均有统计学意义(P<0.05)。结论岭南地区溃疡性结肠炎的中医证候与结肠镜像分型、黏膜组织学分期有明显的相关性,结肠镜及病理组织学检查可作为中医辨证的客观化指标。Objective To study the relationship between traditional Chinese medicine （TCM） syndrome of ulcerative colitis in Lingnan area and endoscopic classification and mucosal tissue staging, providing the objective basis for the TCM differentiation. Methods A total of 124 patients with ulcerative colitis in Lingnan area were selected. The pro-portions of different clinical TCM syndrome type were analyzed, and the correlations between TCM syndrome type and endoscopic classification and mucosal tissue staging were analyzed. Results The common types of TCM syn-drome of ulcerative colitis in Lingnan area were large intestine damp-heat, spleen-deficiency and dampness-heat, defi-ciency of spleen and stomach qi. TypeⅠendoscopic classification was showed more in large intestine damp-heat than in spleen-deficiency and dampness-heat, deficiency of spleen and stomach qi （P〈0.05）. There was similar probability of TypeⅡendoscopic classification in the three TCM syndrome types. TypeⅢ endoscopic classification was signifi-cantly less showed in large intestine damp-heat than in spleen-deficiency and dampness-heat, deficiency of spleen and stomach qi （P〈0.05）. Large intestine damp-heat was the most common in the active phase of mucosal tissue staging （P〈0.05）, while spleen-deficiency and dampness-heat as well as deficiency of spleen and stomach qi occupied main positions in the relieving phase of mucosal tissue staging （P〈0.05）. Conclusion The TCM syndrome of ulcerative colitis in Lingnan area has an significant relationship between endoscopic classification and mucosal tissue staging, and endoscopic classification and mucosal tissue staging may provide objective basis for the TCM differentiation.

关 键 词：岭南地区 溃疡性结肠炎 中医证候 结肠镜 黏膜组织学 

分 类 号：R574.62[医药卫生—消化系统]