不同自主神经干预对家犬交感神经系统的影响  

Effects of different autonomic nervous intervention on the sympathetic nerve system in dogs

作　　者：周丽平[1] 余锂镭[1] 王卓[1] 黄兵[1] 王松云[1] 廖凯[1] 萨仁高娃[1] 江洪[1] 

机构地区：[1]武汉大学人民医院心内科,湖北武汉430060

出　　处：《海南医学》2015年第18期2657-2661,共5页Hainan Medical Journal

基　　金：国家自然科学基金(编号:81270339;81300182);中央高校基本科研业务费专项资金(编号:2042012kf1099;2042014kf0110);湖北省自然科学基金(编号:2013CFB302);武汉市科技攻关计划项目基金(编号:201306060201010271);武汉大学博士研究生自主科研项目(编号:2012302020206)

摘　　要：目的研究不同自主神经干预方法对家犬交感神经系统的影响。方法 40只成年家犬随机分为肾交感神经消融(RSD)组(n=8)、低强度耳缘迷走神经刺激(LL-TS)组(n=8)、低强度颈动脉窦压力感受器刺激(LL-CBS)组(n=8)、低强度脊髓神经刺激(LL-SCS)组(n=8)和对照组(n=8)。分别在基础状态、干预1 h、2 h和3 h末测定同等电压强度高频电刺激左侧星状神经节(LSG)时的血压变化,并以血压变化最大值代表LSG功能。在基础状态和干预3 h末测定LSG神经活性和血浆去甲肾上腺素(NE)水平。结果基础状态时,对照组与RSD、LL-TS、LL-CBS和LL-SCS各干预组高频刺激LSG时诱导的血压变化最大值、LSG神经活性和血浆NE水平比较差异均无统计学意义(P>0.05)。干预3 h后,RSD、LL-TS、LL-CBS和LL-SCS各干预组LSG功能、神经活性和血浆NE水平均比对照组明显降低,差异均有统计学意义(P<0.05)。结论 RSD、LL-TS、LL-CBS和LL-SCS这几种自主神经干预方法都可以显著抑制LSG的功能和活性以及系统交感神经活性。Objective To investigate the effects of different autonomic nervous intervention on the sympa-thetic nerve system in dogs. Methods Forty dogs were randomly divided into the renal sympathetic nerve denerva-tion （RSD） group （n=8）, the low-level tragus stimulation （LL-TS） group （n=8）, the low-level carotid baroreceptor stim-ulation （LL-CBS） group （n=8）, the low-level spinal cord stimulation （LL-SCS） group （n=8） and the control group （n=8）. Blood pressure （BP） at baseline and 1 h, 2 h, 3 h after stimulation were recorded, and the maximum BP increasing value when high frequency stimulation （HFS） was delivered to left stellate ganglion were measured as the function of the left stellate ganglion. The nerve activity of LSG and the NE level of plasma were also measured. Results At baseline state, there were no significant differences between the control group and RSD group, LL-TS groups, LL-CBS group, LL-SCS group in the maximum BP increasing value, the LSG activity and the NE level （P〉0.05）. After 3 hours of auto-nomic intervention, the maximum BP increasing value, the LSG activity and the NE level of RSD group, LL-TS group, LL-CBS group, LL-SCS group were significantly lower than those of the control group. Conclusion Autonomic inter-vention by RSD, LL-TS, LL-CBS and LL-SCS could significantly decrease the activity and function of left stellate ganglion and the activity of systematic sympathetic nerve.

关 键 词：自主神经系统 星状神经节 神经活性 

分 类 号：R-332[医药卫生]