磷酸镁/PBS/小麦蛋白复合骨修复材料  

Magnesium Phosphate/PBS/Wheat Protein Biocomposite for Bone Repair

作　　者：王泉翔 邬迎阳 董谢平[2] 马旭辉 魏杰[1] 

机构地区：[1]华东理工大学生物材料工程研究中心,上海200237 [2]江西省人民医院骨科,南昌330006 [3]深圳科聚新材料有限公司,深圳518101

出　　处：《无机材料学报》2015年第9期957-962,共6页Journal of Inorganic Materials

基　　金：国家科技支撑计划(2013BAI05B10);深圳市战略新兴产业发展专项科资金(CXZZ2012070355537097)~~

摘　　要：采用共沉淀法合成磷酸镁,将磷酸镁(MP)、聚丁二酸丁二醇酯(PBS)和小麦蛋白(WP)进行复合,制备出MP/PBS/WP复合骨修复材料。通过体外降解、生物活性以及细胞培养等实验对复合材料的理化性能及细胞相容性进行了研究。结果显示:MP/PBS/WP复合材料在Tris-HCl缓冲液中浸泡10 d后,溶液p H从7.4上升至7.51,浸泡12 w后,其降解率达到58.43wt%;复合材料在模拟体液中浸泡10 d后,其表面形成磷灰石层;复合材料能促进MC3T3-E1细胞的增殖与分化。结果表明:MP/PBS/WP复合材料具有优良的降解性、生物活性和细胞相容性,有望成为一种新型骨修复材料。Magnesium phosphate was prepared through coprecipitation method, and biocomposite containing magnesium phosphate（MP）, polybutylene succinate（PBS） and wheat protein（WP） was fabricated. In vitro degradability, bioactivity and cell responses to MP/PBS/WP composite were investigated. The results showed that the p H value changed from 7.4 to 7.51 after the MP/PBS/WP composite being soaked in Tris-HCl buffer solution for 10 d. The weight loss of the composite reached 58.43wt% after soaking for 12 w. Apatite layer could form on the composite surfaces after soaking in SBF solution for 10 d, indicating good bioactivity. In addition, the MP/PBS/WP composite could promote proliferation and differentiation of MC3T3-E1 cells. All data from this study show that the MP/PBS/WP composite has good degradability, bioactivity and cytocompatibility, showing a potential to be used as a new biomaterial for bone repair.

关 键 词：磷酸镁 PBS 小麦蛋白 生物复合材料 骨修复 

分 类 号：TB383[一般工业技术—材料科学与工程]