骨质疏松症~1H-MRS脂肪分数定量研究:Meta分析  

Fat fraction value measured by proton magnetic resonance spectroscopy in osteoporosis:a Meta analysis

作　　者：张慈慈 沈思[1] 汪飞[1] 邱麟[1] 刘斯润[1] 

机构地区：[1]暨南大学附属第一医院影像中心,广州510630

出　　处：《国际医学放射学杂志》2015年第5期409-412,共4页International Journal of Medical Radiology

摘　　要：目的采用Meta分析的方法综合评价1H-MRS相对定量指标脂肪分数与骨质疏松症骨密度的关系,探索脂肪分数能否如骨密度一样成为诊断骨质疏松症的可靠指标。方法检索Pubmed、Cochrane图书馆、Medline、中国知网(CNKI)等数据库中2000年1月—2014年12月公开发表的有关1H-MRS评价骨质疏松的中英文文献,提取文献中骨质疏松组与正常组的相对定量指标(脂肪分数),以及脂肪分数与骨密度的Pearson相关系数r值。采用review manager 5.0统计学软件对纳入文献的脂肪分数进行Meta分析,获得汇总加权均数差(WMD)及95%CI;并对脂肪分数与骨密度的Pearson相关系数r进行分析。结果纳入9篇文献(英文7篇,中文2篇),共499例病人(正常组210例,骨质疏松组289例)。Meta分析结果显示,骨质疏松组的脂肪分数高于正常组,汇总WMD为9.25(95%CI:6.95~11.56);通过合并Pearson相关系数r分析,脂肪分数与骨密度呈负相关(-0.59,95%CI:-0.76^-0.42)。结论 1H-MRS测量的脂肪分数在评价骨质疏松症中有一定的临床价值,可作为双能X线吸收法的补充检查。其能否像骨密度一样成为诊断骨质疏松症的可靠指标,可行性及准确性需要更多的研究。Objective To have a systemic review of the association between fat fraction value measured by proton magnetic resonance spectroscopy and osteoporosis bone mineral density, and to explore if fat fraction can be a reliable indicator for the diagnosis osteoporosis like bone mineral density. Methods Pubmed, Cochrane library, Medline, and China National Knowledge Infrastructure （CNKI） datebases （from January, 2000 to December, 2014） were searched to collect articles about proton magnetic resonance spectroscopy assessing osteoporosis. The data of fat fraction in osteoporosis group and normal group and Pearson correlation coefficient between bone mineral density and fat fraction were extracted from the articles. Pooled weighted mean difference （WMD） and 95%confidence interval, Pearson correlation coefficient between bone mineral density and fat fraction were done using review manager 5. 0 software. Results Nine articles （seven English articles, two Chinese articles） were included with 499 cases （210 normal and 289 osteoporosis）. The fat fraction value was higher in osteoporosis than normal （WMD 9.25, 95%CI：6.95 to 11.56）. A negative correlation was found between fat fraction value and bone mineral density （-0.59,95%CI：-0.76^-0.42）. Conclusion Fat fraction measured by Proton magnetic resonance spectroscopy has certain clinical value in the assessment of osteoporosis, it can be used as a supplemental examination of DXA. Whether it can be a reliable indicator for the diagnosis osteoporosis like bone mineral density, the feasibility and accuracy need more research.

关 键 词：骨质疏松 磁共振波谱 骨密度 脂肪分数 META分析 

分 类 号：R743.31[医药卫生—神经病学与精神病学]