转换控制器介导的多电极同步消融离体牛肝的影响因素分析  

Analyze the factors influencing multi-electrode synchronous radiofrequency ablation via switching controller in ex vivo bovine liver

作　　者：张艳阳[1] 顾仰葵[1] 黄金华[1] 高飞[1] 江雄鹰[2] 张天奇[1] 黄森渺 

机构地区：[1]中山大学附属肿瘤医院影像与微创介入中心华南肿瘤学国家重点实验室,广州510060 [2]中山大学孙逸仙纪念医院放射介入专科

出　　处：《中华医学杂志》2015年第35期2871-2874,共4页National Medical Journal of China

基　　金：国家自然科学基金（81371652）;广东省省计划项目（20128031800120）

摘　　要：目的 探讨不同电极裸露端长度、不同消融时间对转换器介导的多电极同步消融离体牛肝消融灶大小的影响.方法 2014年12月至2015年2月在中山大学实验动物中心采用Cool-tip转换控制器介导的多电极同步射频消融设备,以不同电极裸露端长度（2、3、4 cm）和不同消融时间（12、16、20、24 min）为变量形成12种组合消融新鲜离体牛肝,测量消融灶纵径、横径并计算其体积,采用单因素方差分析法、t检验分析消融灶大小的影响因素.结果 裸露端3 cm电极形成消融灶类圆率更接近1.当采用裸露端4 cm、电极消融24 min时消融灶达到最大,纵径为（7.66±0.21） cm、横径为（6.50 ±0.34） cm、体积为（172±12） cm3.在消融时间一定时,消融灶纵径、横径、体积随着电极裸露端的长度增加而增大,除裸露端3、4 cm电极的横径差异无统计学意义外,各组指标差异均有统计学意义（均P＜0.01）.在电极裸露端长度一定时,消融灶纵径、横径、体积总体上随着消融时间的增加而增大,但除了裸露端4 cm电极在消融时间20、24 min的消融灶纵径和体积差异均有统计学意义（均P＜0.05）外,其余各组在相邻时间点的消融灶纵径、横径和体积差异均无统计学意义.结论 在电极裸露端2～4 cm、消融时间12 ～ 24 min范围内,Cool-tip转换控制器介导的多电极同步射频消融灶的大小随电极裸露端长度和消融时间的增加而增大,其中裸露端3 cm电极形成消融灶更近似圆球体.Objective To investigate the effects of different electrode exposed end and different ablated time on lesion size of Cool-tip multi-electrode synchronous radiofrequency ablation via switching controller in ex vivo bovine liver.Method Twelve combinations of different electrode exposed end （2 cm,3 cm and 4 cm） were used,and different ablated time （12,16,20 and 24 mins） was as experimental parameter.Ablated lesions in longitudinal diameter,transverse diameter and volume were measured.Analyze the factors influencing the lesion size with ANOVA or t test.Results The ablated lesions with 3 cm exposed end electrodes were more stable and the spheroidal rate is more close to 1.When ablated 24 mins with 4 cm exposed end electrodes,the longitudinal diameter,transverse diameter and volume were （7.66 ± 0.21）,（6.50±0.34） cm and （172 ± 12） cm3,respectively.When the ablated time was constant,the lesions increased with the exposed end length of the electrodes increased.All the data among groups was statistically significant （P 〈 0.01） unless the transverse diameters between 3 and 4 cm exposed end electrode.When the exposed end length of electrodes was constant,the lesions increased with the ablated time increased as a whole.But there was no significant difference in most of the adjacent groups.Only the longitudinal diameters and volumes of 4 cm exposed end electrodes between 20 and 24 min were statistically significant（P 〈 0.05） Conclusion Within the experimental range,the lesion size ablated by Cool-tip multi-electrode synchronous radiofrequency ablation via switching controller increased with the electrode exposed end and ablated time increased.The spheroidal rate of the ablated lesions with 3 em exposed end is more close to 1.

关 键 词：消融技术 电极 肝肿瘤 转换器 

分 类 号：R735.7[医药卫生—肿瘤]