Quantification of selected monohydroxy metabolites of polycyclic aromatic hydrocarbons in human urine  

作　　者：Libin Liu Yueping Luo Junping Bi Haifang Li Jin-Ming Lin 

机构地区：[1]Key Laboratory of Monitoring for Heavy Metal Pollutants [2]Hunan Province Environmental Monitoring Centre [3]Beijing Key Laboratory of Microanalytical Methods and Instrumentation [4]Department of Chemistry, Tsinghua University

出　　处：《Science China Chemistry》2015年第10期1579-1584,共6页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21227006,21275088);the China Equipment and Education Resources System(CERS-1-75)

摘　　要：An analytical method was developed to quantitatively determine selected monohydroxy metabolites of polycyclic aromatic hydrocarbons(PAHs) in human urine. The procedure included enzymatic hydrolysis to cleave the conjugated metabolites, solid-phase microextraction enrichment, and gas chromatography-mass spectrometry analysis. The method proved to be sensitive enough to detect the selected PAH metabolites in human urine.An analytical method was developed to quantitatively determine selected monohydroxy metabolites of polycyclic aromatic hydrocarbons（PAHs） in human urine. The procedure included enzymatic hydrolysis to cleave the conjugated metabolites, solid-phase microextraction enrichment, and gas chromatography-mass spectrometry analysis. The method proved to be sensitive enough to detect the selected PAH metabolites in human urine.

关 键 词：polycyclic aromatic hydrocarbons METABOLITES human urine solid-phase microextraction GC/MS 

分 类 号：R446.12[医药卫生—诊断学] O625.15[医药卫生—临床医学]