IFN-γR和sIL-2R在复发性口腔溃疡患者血浆中的表达及意义  

The expression and significance of IFN-γR and s IL-2R in plasma of patients with recurrent oral ulcer

作　　者：马晓喆 李言君[1] 付爱丽 薛江楠[3] 于平 

机构地区：[1]滨州医学院附属医院,256603 [2]烟台市解放军107医院 [3]滨州医学院 [4]烟台市口腔医院

出　　处：《实用口腔医学杂志》2015年第5期656-659,共4页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:81273200)

摘　　要：目的:检测复发性口腔溃疡(ROU)患者血浆中可溶性白细胞介素2受体(s IL-2R)的浓度以及辅助性T细胞(Th)表面干扰素γ受体(IFN-γR)的表达情况。方法:分离21例ROU患者和21例健康人的外周血单个核细胞,采用流式细胞术测定CD+4T细胞上IFN-γR的表达量,ELISA检测外周血s IL-2R的表达水平。结果:ROU患者Th细胞表面的IFN-γR表达水平高于正常对照组(P<0.05),ROU患者外周血s IL-2R的表达也高于正常对照组(P<0.05)。结论:IFN-γR以及s IL-2R分别在ROU患者CD+4T细胞表面及外周血中的高表达与疾病相关。Objective：To examine the plasma soluble interleukin 2 receptor （sIL-2R）and the expression of IFN-γR in helper T （Th）cells in peripheral blood of patients with recurrent oral ulcer（ROU）.Methods：The peripheral blood was obtained from 21 pa-tients in active stage of ROU and 21 healthy controls.Flow cytometry was used to detect the quantity of IFN-γR in CD ＋4 T cells,ELISA was used to detect the level of sIL-2R.Results：The expression of IFN-γR in CD ＋4 T cells and sIL-2R content in plasma of the patients with ROU were significantly higher than those in the healthy controls（P 〈0.05）.Conclusion：Over expression of IFN-γR in CD ＋4 T cells and sIL-2R in peripheral blood may be related to the genesis of ROU.

关 键 词：复发性口腔溃疡 辅助性T细胞 干扰素Γ 干扰素γ受体 白介素2 可溶性白细胞介素2受体 

分 类 号：R781.5[医药卫生—口腔医学]