Slug、EMMPRIN和E-cadherin在唾液腺腺样囊性癌中的表达及意义  

The expression and significance of Slug,EMMPRIN and E-cadherin in salivary adenoid cystic carcinoma

作　　者：周子超[1] 胡志强[2] 吴宝磊[2] 贾森[2] 雷德林[2] 杨新杰[2] 

机构地区：[1]第四军医大学学员旅,西安710032 [2]第四军医大学口腔医学院口腔颌面外科.军事口腔医学国家重点实验室

出　　处：《实用口腔医学杂志》2015年第5期664-668,共5页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:81302352;81372901)

摘　　要：目的:研究Slug、EMMPRIN和E-cadherin在唾液腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)中的表达情况与临床病理特征间的关系及三者表达的相关性。方法:免疫组织化学染色方法检测115例SACC组织中Slug、EMMPRIN和E-cadherin的表达情况,结合临床病理资料进行统计学分析。结果:115例SACC标本中Slug和EMMPRIN阳性表达率分别为76.5%和69.6%,E-cadherin阳性表达率为51.3%。Slug和EMMPRIN的表达与SACC肿瘤病理分型、临床分期、神经侵袭、复发、远处转移呈显著相关(P<0.05),E-cadherin的表达与肿瘤病理分型、临床分期、神经侵袭、远处转移呈显著负相关(P<0.05)。同时,Slug的表达与EMMPRIN的表达呈显著正相关(P<0.05);EMMPRIN、Slug的表达与E-cadherin的表达均呈显著的负相关(P<0.05)。结论:Slug、EMMPRIN和E-cadherin在SACC中的表达与SACC的临床病理特征密切相关。Objective：To investigate the expression of Slug,EMMPRIN and E-cadherin in salivary adenoid cystic carcinoma （SACC）and its correlation with clinicopathological characteristics,and the correlation among themselves.Methods：Slug,EMMPRIN and E-cadherin expression in 1 1 5 SACC cases of SACC was examined by immunohistochemical staining.The results and clinicopatho-logical data were statistically analyzed.Results：High positive expression frequencies of Slug（76.5%）and EMMPRIN（69.6%）and low positive expression frequency of E-cadherin（51 .3%）were found in 1 1 5 SACC cases.The expression of Slug and EMMPRIN was positively associated with the histopathological types,clinical stages,perineural invasion,recurrence and distance metastasis（P 〈0.05）.The expression of E-cadherin was negatively associated with the histopathological types,clinical stages,perineural invasion and distance metastasis（P 〈0.05）.There was a significant correlation between Slug and EMMPRIN expression（P 〈0.05）,negative correlation between EMMPRIN and E-cadherin expression（P 〈0.05）and between Slug and E-cadherin expression（P 〈0.05）.Con-clusion：The expression of Slug,EMMPRIN and E-cadherin is closely correlated to the clinicopathological characteristics of SACC.

关 键 词：SLUG EMMPRIN E-CADHERIN 唾液腺腺样囊性癌 肿瘤转移与侵袭 

分 类 号：R739.87[医药卫生—肿瘤]