影响卵巢内胚窦瘤进展的相关因素分析  

Analysis of factors related to the progression of ovarian endodermal sinus tumor

作　　者：郭杨垄 朱笕青[1] 

机构地区：[1]浙江省肿瘤医院妇瘤外科,浙江杭州310022

出　　处：《中国现代医生》2015年第25期54-58,F0003,共6页China Modern Doctor

基　　金：浙江省自然科学基金(Y2100593)

摘　　要：目的分析卵巢内胚窦瘤临床特点及探讨影响该病进展的相关因素。方法回顾性分析我院2000年1月~2014年6月收治的45例初治卵巢内胚窦瘤或以内胚窦瘤为主的混合性生殖细胞肿瘤患者临床资料,通过影像学及血清学指标判断该病是否进展,评价无疾病进展生存时间,比较相关因素（年龄、生育史、术后残余肿瘤、病理类型、FIGO分期、术后含铂化疗疗程数）对该病进展的影响。结果单因素分析中,FIGO分期Ⅰ~Ⅱ期、术后无残余肿瘤、术后含铂化疗疗程数≥3个是影响该病进展的独立因素,发病年龄、生育史、病理类型并不影响该病的进展。在多因素分析中,发病年龄、生育史不影响该病的进展,术后含铂化疗疗程数及病理类型对该病进展的影响显著,而FIGO分期、术后残余肿瘤对该病进展作用有限。结论发病年龄、生育史不影响该病的进展,FIGO分期、术后残余肿瘤、术后含铂化疗疗程数是影响该病进展的独立因素,然而只有术后含铂化疗疗程数对该病进展的影响显著,FIGO分期、术后残余肿瘤对该病进展的影响作用有限。另外,病理类型可能对该病进展有显著影响。Objective To analyze the clinical characteristics and to explore the related factors of progression in ovarian endodermal sinus tumor. Methods A retrospective analysis of 45 ovarian endodermal sinus tumor or mixed germ cell tumors with majority of endodermal sinus tumor in our hospital from January 2000 to June 2014 was performed. The progression of the disease was judged by imaging and serum markers, and the progression-free survival of the disease was evaluated. Comparing the influence of related factors（age, childbearing history, postoperative residual tumor,pathological type, FIGO stage, course number of postoperative platinum containing chemotherapy） on the progression of the disease was performed. Results Tumor FIGO stage which showed stage I or II, no postoperative residual tumor,course number of postoperative platinum containing chemotherapy which was more than or equal to 3 were independent factors affecting the progression of the disease. However, age, childbearing history and pathological type did not affect the progression of the disease. Multivariate analyses illustrated that age and childbearing history did not affect the progression of the disease. In addition, course number of postoperative platinum containing chemotherapy and pathological type had significant effect on the progression of the disease. However, FIGO stage, postoperative residual tumor had only limited influence on the progression of the disease. Conclusion Age and childbearing history did not affect the progression of the disease. FIGO stage, postoperative residual tumor and course number of postoperative platinum containing chemotherapy were independent factors affecting the progression of the disease. Course number of postoperative platinum containing chemotherapy had significant effect on the progression of the disease while FIGO stage, postoperative residual tumor had only limited influence on the progression of the disease. In addition, pathological type might have significant effect on the progression of the disease.

关 键 词：卵巢内胚窦瘤 肿瘤进展因素 FIGO分期 术后残余肿瘤 术后含铂化疗疗程数 病理类型 

分 类 号：R737.31[医药卫生—肿瘤]