放射性碘治疗分化型甲状腺癌患者生存质量分析  

Analysis of the quality of life of radioactive iodine therapy in patients with differentiated thyroid carcinoma

作　　者：陈东方[1] 楼岑[2] 牟达[2] 权友琼[2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院下沙院区(杭州市下沙医院)核医学科,浙江杭州310018 [2]浙江大学医学院附属邵逸夫医院核医学科,浙江杭州310016

出　　处：《中国现代医生》2015年第25期62-65,69,共5页China Modern Doctor

基　　金：浙江省自然科学基金资助项目(LQ14H180004)

摘　　要：目的探讨放射性碘治疗分化型甲状腺癌的生存质量情况。方法选择2014年1~9月放射性碘治疗的分化型甲状腺癌患者44例为研究对象,分别于术后初次行放射性碘治疗前1个月及治疗后1个月评估患者生命质量。同时选择健康体检者40例为对照组。统计分析患者治疗后的生命质量,评估患者预后。结果研究组治疗后情绪功能评分下降,气促程度下降,差异有统计学意义（P〈0.05）。研究组治疗后,躯体功能、情绪功能、认知功能、社会功能、总体健康状况、疲倦、恶心呕吐、疼痛、气促、食欲丧失、经济困难与对照组比较差异有统计学意义（P〈0.05）。放射性碘治疗分化型甲状腺癌患者生存质量相关因素分析：性别与患者失眠有关,年龄与患者躯体功能、疼痛、失眠有关,文化水平与经济困难有关,病理分期与躯体功能、疲倦、食欲、便秘有关,危险分层与躯体功能、疲倦、食欲、气促有关,手术方式与总体健康状况有关（P〈0.05或P〈0.01）。结论分化型甲状腺癌术后以及放射性碘治疗后患者总的生存质量较健康人群差。放射性碘治疗后患者的生存质量与术后比较,总体差异不明显,但情绪功能较治疗前较差。女性、年龄大、文化程度低、病理分期高、危险分层高、手术范围大等影响患者的生存质量。Objective To analyze the quality of life of radioactive iodine therapy in patients with differentiated thyroid carcinoma. Methods A total of 44 cases with differentiated thyroid carcinoma treated with radioactive iodine from Jan to Nov 2014 were selected as subjects. The quality of life of patients was assessed on one month before and after the first time radioactive iodine treatment after operation. 40 cases of healthy examination were selected as control group. Quality of life of patients was evaluated after treatment, and prognosis was assessed. Results Emotional function score of study group was lower after treatment, and dyspnea degree was less （P〈O.05）. Physical function, emotional function, cognitive function, social function, general health, fatigue, nausea, vomiting, pain, shortness of breath, loss of appetite, economic difficulties of study group after treatment were significant different compared with control group （P〈0.05）. Analysis of relating factors of the quality of life of radioactive iodine therapy in patients with differentiated thyroid carcinoma showed that： gender was related to patient insomnia, age was related to physical function, pain and insomnia, education was related to economic difficulties, staging was related to physical function, fatigue, loss of appetite and con- stipation, risk stratification was related to physical function, fatigue, loss of appetite, shortness of breath, and surgical approach was related to overall heahh（P〈O.05 and P〈0.O1 ）. Conclusion Quality of life of patients with differentiated thyroid carcinoma after operation and radioactive iodine therapy is bad compared with healthy people. The quality of life of patients after radioiodine therapy is not obviously different compared with postoperative, but emotional function- ing is bad. Female, older, less educated, high pathological stage, high risk stratification and large operation range affect the quality of life of patients.

关 键 词：放射性碘治疗 分化型甲状腺癌 生存质量 预后 

分 类 号：R736.1[医药卫生—肿瘤]