姜黄素对小鼠爆发性肝炎的作用研究  

Therapeutic effect of curcumin on bacteria-induced fulminant hepatitis in mice

作　　者：顾巧丽[1] 蔡燕[1] 杨惠林[1] 施勤[1] 

机构地区：[1]苏州大学附属第一医院,苏州215006

出　　处：《现代免疫学》2015年第5期358-361,共4页Current Immunology

基　　金：国家自然科学基金青年基金(81301341);江苏省博士后基金(1302106B)

摘　　要：探讨姜黄素对痤疮丙酸杆菌(propionibacterium acnes,P.acnes)/LPS诱导的小鼠爆发性肝炎的影响。实验分为正常组,对照组和姜黄素组。分别给予赋形剂或姜黄素治疗,7d后处死小鼠,评价治疗效果及检测相关免疫学指标。结果显示,和对照组相比,姜黄素给药显著提高小鼠生存率,降低血清谷丙转氨酶水平;降低肝脏CD4+T细胞数量和BrdU表达,降低巨噬细胞MHCⅡ、CD80和CD86表达。结果表明,姜黄素能缓解P.acnes/LPS诱导的爆发性肝炎,其机制可能与抑制CD4+T细胞浸润、增殖及巨噬细胞活化有关。The effect of eurcumin on fulminant hepatitis was investigated using a mouse model induced by P. acnes/LPS. Curcumin or vehicle control was administered by gavage once daily after P. aches priming. Efficacy of curcumin was monitored and some immune indices were examined. The results showed that curcumin reduced the severity of P. acnes/LPS-induced liver in- jury, accompanied by decreased serum ALT level. Curcumin significantly inhibited the infiltration and proliferation of CD4^＋ T cells. In addition, curcumin reduced the expression of MHC Ⅱ , CD80 and CD86 on macrophages. The data suggest that curcumin protects mice from P. acnes/LPS-indueed liver injury by inhibiting CD4^＋ T cell infiltration, proliferation, and maerophage activation.

关 键 词：姜黄素 爆发性肝炎 CD4^+T细胞 巨噬细胞 

分 类 号：R575.1[医药卫生—消化系统]