Substance P and its tachykinin NK1 receptor: a novel neuroprotective target for Parkinson's disease  

作　　者：Emma Thornton Robert Vink 

机构地区：[1]School of Medical Sciences, University of Adelaide, Adelaide, Australia [2]Division of Health Sciences, University of South Australia

出　　处：《Neural Regeneration Research》2015年第9期1403-1405,共3页中国神经再生研究（英文版）

基　　金：in part has been supported by the Neurosurgical Research Foundation, South Australia, Australia

摘　　要：Parkinson＇s disease （PD） is the most common motor neurode- generative disorder affecting approximately 4 million people worldwide. Although PD presents primarily with motor dysfunction, non-motor symptoms including cognitive decline, mood disorders, reduced olfaction and constipation are also of- ten present, with some of these non-motor symptoms even pre- senting prior to the onset of motor symptoms. It is well known that PD is largely caused by the gradual degeneration of dopa- minergic neurons within the substantia nigra pars compacta （SNc）, along with the presence of protein aggregates called Lewy bodies, which consist primarily of ct-synuclein and are found in the cytoplasm of surviving neurons. This ongoing cell loss and Lewy body pathology is not confined to the SNc, but is also seen in other brain regions implicated in PD pathogenesis such as the locus ceruleus.Parkinson＇s disease （PD） is the most common motor neurode- generative disorder affecting approximately 4 million people worldwide. Although PD presents primarily with motor dysfunction, non-motor symptoms including cognitive decline, mood disorders, reduced olfaction and constipation are also of- ten present, with some of these non-motor symptoms even pre- senting prior to the onset of motor symptoms. It is well known that PD is largely caused by the gradual degeneration of dopa- minergic neurons within the substantia nigra pars compacta （SNc）, along with the presence of protein aggregates called Lewy bodies, which consist primarily of ct-synuclein and are found in the cytoplasm of surviving neurons. This ongoing cell loss and Lewy body pathology is not confined to the SNc, but is also seen in other brain regions implicated in PD pathogenesis such as the locus ceruleus.

关 键 词：NK a novel neuroprotective target for Parkinson’s disease Substance P and its tachykinin NK1 receptor 

分 类 号：R742.5[医药卫生—神经病学与精神病学]