内蒙古牧区蒙古族、汉族老年人群血管性危险因素与阿尔茨海默病关系的病例-对照研究  

Epidemiology based case-control study of relationship between Alzheimer's disease and vascular risk factors of Mongolian and Han population aged people living in Inner Mongolia pastoral area

作　　者：王德泉 呼日勒特木尔 张国华[2] 贺娟[2] 王智光[2] 江名芳[2] 张春雨[2] 

机构地区：[1]兴安盟科右中旗人民医院内二疗区,内蒙古029400 [2]内蒙古医学院第一附属医院神经科,呼和浩特010050

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第4期5-9,共5页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：2013年内蒙古自治区科技厅应用技术研究与开发资金资助(20130402);内蒙古教育厅青年科技领军人才项目资助(jyt13pnyco);内蒙古自治区自然科学基金(2014MS0848)

摘　　要：目的探讨内蒙古牧区蒙古族、汉族55岁以上人群血管性危险因素与阿尔茨海默病(AD)患病的相关性。方法以AD的流行病学调查为基础,同时详细记录受试者的血管性危险因素,采用非条件Logistic回归分析方法对血管性危险因素和AD的关系进行分析。结果在蒙古族55岁以上人群中,脉压指数、糖尿病患病率、冠心病患病率在对照组与AD组之间的差异有统计学意义(t=-2.091,P=0.037;χ2=7.230,P=0.007;χ2=13.859,P=0.000);而在汉族55岁以上人群中,对照组与AD组之间脉压指数、冠心病患病率比较差异有统计学意义(t=-2.232,P=0.026;χ2=6.951,P=0.008),对照组糖尿病患病率与AD组之间的差异无统计学意义(P>0.05)。多因素分析显示,蒙古族55岁以上人群糖尿病、冠心病在对照组与AD组之间的差异有统计学意义,是AD的危险因素(OR=2.423,OR=2.030,均P<0.05);在汉族55岁以上人群中冠心病、脉压指数在对照组与AD组之间的差异同样具有统计学意义,是AD的危险因素(OR=1.662,OR=7.078,均P<0.05)。结论血管性因素可能是中国内蒙古牧区蒙古族、汉族55岁以上人群患AD的危险因素,血管性危险因素可能在AD的发病之中具有协同作用。Objective To investigate the relationship between vascular risk factors and Alzheimer′s disease（AD） in Mongolian and Han population over 55 years old living in Inner Mongolia pastoral areas . Methods Based on the epidemiological investigation of AD ,the subjects′vascular risk factors were recoded in detail and non-conditional logistic regression analysis was adopted to analyze the relation between vascular risk factors and AD.Rse ults Among the people of Mongolian nationality aged over 55,there were statistical differences in pulse pressure index , diabetes rate and coronary heart disease （ CHD ） rate between control group and AD group （ t=-2.091 , P=0.037;χ2 =7.230 , P =0.007;χ2 =13.859 , P=0.000 ）;In Han nationality′s people aged over 55, there was statistical difference in pulse pressure index and CHD rate between control group and AD group （ t =-2.232 , P =0.026;χ2 =6.951 , P =0.008 ） .There was no statistical difference in diabetes between control group and AD group （ P 〉0.05 ） .Multivariate analysis showed that the differences of diabetes and CHD between control group and AD group had statistically＆amp;nbsp;significance in Mongolian populations aged over 55,diabetes and CHD were risk factors of AD （OR=2.423, OR=2.030 , all P〈0.05 ）;The differences of CHD , pulse pressure index between control group and AD group also had statistically significant in Han populations aged over 55,CHD,pulse pressure index were risk factors of AD（OR=1.662,OR=7.078,all P〈0.05）.Conclusion Vascular factors may be the risk factors of the Mongolian nationality and Han Nationality population aged over 55 living in Inner Mongolia pastoral areas,which may have a synergistic effect on the pathogenesis of AD .

关 键 词：阿尔茨海默病 蒙族 危险因素 血管性因素 

分 类 号：R749.16[医药卫生—神经病学与精神病学]