新辅助化疗在局部晚期口腔癌中的疗效分析  

Clinical curative effect on neoadjuvant chemotherapy in locally advanced oral cavity cancers

作　　者：刘晓楠[1] 卓姗姗 岳玖玲 张文超[1] 张仑[1] 

机构地区：[1]天津医科大学肿瘤医院颌面耳鼻喉肿瘤科,国家肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津300060

出　　处：《天津医科大学学报》2015年第5期408-411,共4页Journal of Tianjin Medical University

摘　　要：目的:探讨新辅助化疗在局部晚期口腔鳞癌中的疗效,分析影响局部晚期口腔癌预后的危险因素。方法:收集行新辅助化疗的局部晚期口腔癌患者的临床病理资料,并对预后影响因素行相关性分析。结果:新辅助化疗有效率为64.8%,完全缓解率为5.6%,部分缓解率为59.2%;肿瘤T分期降低者83例,降低2期者25例,降低1期者58例。患者的中位生存期为29个月,可手术组30个月,不可手术组21个月。多因素分析显示淋巴结转移、手术治疗、游离皮瓣修复、手术切缘为局部晚期口腔癌预后影响因素。结论:新辅助化疗降低局部晚期口腔癌的分期,提高手术率,使患者生存获益。淋巴结转移、手术治疗、游离皮瓣修复、手术切缘是预后的独立危险因素。Objective： To explore the effects of neoadjuvant chemotherapy （NACT） followed by surgery on locally advanced oral cavity cancers and to analyse the prognosis factors. Methods： Clinical pathologic features of patients with locally advanced oral cavity cancers, who were treated with NACT were observed and the prognosis factors were analysed. Results： The response rate of NACT was 64.8%, and the complete response rate （CR） was 5.6%, and the partial response rate （PR） was 59.2%. The conditions of 83 cases at T stage were decreased, 25 of which were decreased for 2 stages while 58 decreased for one stage. The median of estimated OS in patients undergoing surgery was 30 months and 21 months in patients treated without surgery. Regional lymph node metastasis, flap application, resection margin, surgery were identified as independent factors that influence prognosis. Conclusion： NACT could lead to successful resection and improve overall survival in locally advanced oral cavity cancers followed by surgery. Regional lymph node metastasis, flap application, resection margin, surgery are independent risk factors of prognosis.

关 键 词：局部晚期口腔癌 新辅助化疗 手术治疗 可切除率 预后 

分 类 号：R739.8[医药卫生—肿瘤]