DNA damage and repair regulate neuronal gene expression  

作　　者：Yijing Su 

机构地区：[1]Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA [2]Department of Neurology,Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA [3]The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA [4]Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

出　　处：《Cell Research》2015年第9期993-994,共2页细胞研究（英文版）

摘　　要：Neuronal activity-induced gene expression is crucial for the development and plasticity of the brain and for learning and memory. In a recent study published in Cell, Madabhushi et al. report that neuronal activity triggers the formation of DNA double-strand breaks on promoters of early response genes, which in turn controls their expression in neurons.

关 键 词：基因表达 神经元 修复 损伤 CELL 双链断裂 可塑性 记忆 

分 类 号：Q78[生物学—分子生物学] TP18[自动化与计算机技术—控制理论与控制工程]