大头围与低年龄孤独症谱系障碍的相关研究  

Correlation analysis between macrocephaly and autism spectrum disorder in low-aged children

作　　者：郑清文[1] 陈凯云[1] 邓红珠[1] 李巧毅[1] 岑超群[1] 邹小兵[1] 

机构地区：[1]中山大学附属第三医院儿童发育行为中心,广州在读硕士研究生510630

出　　处：《新医学》2015年第9期584-588,共5页Journal of New Medicine

基　　金：国家重点基础研究发展计划(973计划)(2012CB517901)

摘　　要：目的比较大头围孤独症谱系障碍(ASD)患儿与正常头围ASD患儿临床症状差异,分析头围与ASD临床特征之间的关系,探讨大头围作为ASD内表型的临床意义。方法分析36例大头围ASD患儿(大头围组)和103例正常头围ASD患儿(正常头围组)的孤独症诊断会谈问卷-修订版(ADI-R)结果,比较2组ADI-R各诊断项目分值的差异,采用Pearson相关分析头围与ADI-R评估分值的关联性。结果 1大头围组"社会互动异常"分值高于正常头围组(P=0.002);"沟通异常"和"局限/重复/刻板行为模式"的分值在2组间比较差异无统计学意义(P>0.05)。2大头围组男性患儿"社会互动异常"分值高于正常头围组男性患儿(P=0.002),该差异不存在于2组女性患儿间(P>0.05);大头围组≤36个月患儿的"社会互动异常"分值比正常头围组同月龄段患儿高(P<0.001),而2组>36个月的患儿该分值比较差异无统计学意义(P>0.05)。3头围与患儿"社会互动异常"分值呈正相关(r=0.193,P=0.023),未发现头围与患儿"局限/重复/刻板行为模式"分值存在相关性(r=-0.128,P=0.134)。结论与正常头围ASD患儿比较,大头围ASD患儿的社交障碍更突出;头围对于不同年龄、不同性别患儿的影响不同;大头围可能可作为ASD的内表型。Objective To compare the clinical symptoms between autism spectrum disorder （ASD） children with macrocephaly and ASD counterparts with normal head circumference,aiming to analyze the corre-lation between head circumference and clinical characteristics of ASD and investigate the clinical significance of macrocephaly as the endophenotype of ASD.Methods The scores of autism diagnostic interview-revised （ADI-R）of 36 ASD children with macrocephaly （macrocephaly group）and 103 ASD counterparts with normal head circumference （normal head circumference group）were analyzed.The scores of each diagnostic item of the ADI-R were statistically compared between the two groups.The correlations between head circumference and ADI-R scores was analyzed by Pearson correlation analysis.Results ① The “social interaction abnormal-ity”score in the macrocephaly group was significantly higher compared with that in the normal head circumfer-ence group （P =0.002）.The scores of “communication abnormality”and “restricted /repetitive /stereotyped behavioral patterns”did not significantly differ between two groups （P 〉0.05）.② The ASD boys with macro-cephaly had considerably higher score of “social interaction abnormality”than that in their counterparts with normal head circumference （P =0.002）rather than in the affected girls between two groups （P 〉0.05）.The“social interaction abnormality”score in the ASD children with macrocephaly aged ≤ 36 months was consider-ably higher than that in the ASD counterparts with normal head circumference of the same age （P 〈0.001）, whereas no statistical significance was noted in children aged 〉36 months between two groups （P 〉0.05）.③ Head circumference was positively correlated with the score of “social interaction abnormality”（r =0.193, P =0.023）,whereas no correlation was found between head circumference and “restricted /repetitive /stereo-typed behavioral patterns”（r =-0.128,P =0.134）.Conclusions Compared with ASD ch

关 键 词：孤独症谱系障碍 内表型 大头围 社交障碍 

分 类 号：R749.94[医药卫生—神经病学与精神病学]