HPV DNA检测在宫颈病变病人分层管理中的应用  

Application of HPV DNA detection in hierarchical management of patients

作　　者：苏丽[1] 刘海清[1] 席丽军[1] 任晶[1] 冯丽艳[1] 英丹[1] 

机构地区：[1]大庆龙南医院(齐齐哈尔医学院第五附属医院)妇产科,黑龙江大庆163453

出　　处：《中国性科学》2015年第9期31-34,共4页Chinese Journal of Human Sexuality

摘　　要：目的：探讨不同HPV感染型别、不同年龄等对宫颈病变发展程度的影响,用于指导病人分层管理的合理策略。方法：采用凯普医用核酸分子快速导流杂交基因芯片技术,对2012年4月至2013年3月就诊于我院妇产科的1070名女性进行生殖道21种人乳头瘤病毒（HPV）分型检测。结果：HPV总感染率17.20%,常见感染型别依次为HPV16（27.17%）,HPV58（21.20%）,HPV31（11.96%）,HPV52（9.24%）及HPV18（7.07%）。20~25岁和55~59岁两个年龄段,HPV阳性率最高,但40~44岁HPV16、33、31三种高危型阳性率最高。35~39岁CINⅡ及以上病变的比率最高。结论：不同情况的HPV阳性病人需分层管理,区别对待。Objectives：To investigate the effects of different HPV genotypes and different ages on the grade of cervical lesions and to provide a reasonable strategy for patient’s hierarchical management.Methods：Specimens from 1070 women who visited the Longnan Hospital from April 2012 to March 2013 were tested for HPV genotypes by flow -through hybridization and gene chip technology.Results：The infection rate of HPV was 17.20%.The most common HPV genotypes were HPV16 （27.17%）,HPV58 （21.20%）,HPV31 （11.96%）,HPV52 （9.24%）and HPV18 （7.07%）.The age groups with the highest positive rate were group 20 ~25 and group 55 ~59.But group 40 ~44 had the highest positive rate of high risk type of HPV 16,33 and 31.The grade of cervical lesions in group 35 ~39 was the highest.Conclusions：It is necessary to differentiate different HPV -positive patients.

关 键 词：人乳头瘤病毒 基因型别 年龄 宫颈上皮内瘤变 

分 类 号：R737[医药卫生—肿瘤]