血脂水平与脑血流动力学综合指标关系的研究  

A study on the relationship between lipid levels and cerebrovascular hemodynamic comprehensive indexes

作　　者：郭吉平[1] 王艳[1] 杨永举[1] 曹奕丰[1] 顾桢茂[1] 刘广西[1] 李学松[1] 黄久仪[1] 

机构地区：[1]上海市脑血管病防治研究所,上海201203

出　　处：《中国慢性病预防与控制》2015年第9期653-656,660,共5页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家"十二五"科技支撑计划课题(2011BAI08B01)

摘　　要：目的了解社区人群血脂水平与脑血流动力学综合指标的关系，为脑卒中预防和危险因素研究提供参考。方法2012年8-12月，整群抽取上海奉贤区2个社区55-79岁的人群5153人，基线调查时测定脑血流动力学检测指标（CVHI）和空腹血脂水平，根据统一的规则计算CVHI综合积分，并按最佳截断点将研究对象分为CVHI积分值975分组和〈75分组，比较两组间血脂水平，分析血脂水平与CVHI积分值的关系，并进行多因素logistic回归分析。结果研究人群年龄为（64．2±6．4）岁，男性2209例（42．87％），女性2944例（57．13％）。男性、女性CVHI积分值〈75分组的TG水平均显著高于≥75分组，差异均有统计学意义（t值分别为3．995和6．920，P〈0．01）。两组研究对象间的TC水平差异均无统计学意义（办0．05）。女性65～69岁年龄组CVHI积分〈75分组的低密度脂蛋白胆固醇水平显著高于975分组，差异有统计学意义（f=2．078，P〈0．05），其余年龄组两组研究对象的低密度脂蛋白胆固醇水平差异均无统计学意义（P〉0．05）。男性、女性CVHI积分值〈75分组高密度脂蛋白胆固醇水平均显著低于≥75分组，差异均有统计学意义（t值分别为-3．104和-6．912，P〈0．01）。多因素logistic回归分析结果显示，高密度脂蛋白胆固醇水平是CVHI积分值降低的保护因素，年龄、高血压病史、糖尿病病史、超重或肥胖、左心室肥厚、房颤病史、甘油三酯水平和男性为危险因素，其OR值及95％C1分别为0．774（0．598-1．002）、1．075（1．064～1．088）、2．172（1．871～2．521）、2．044（1．625～2．571）、1．684（1．516-1．870）、2．057（1．593～2．657）、2．051（1．080。3．894）、1．179（1．092—1．273）和1．543（1．326～1．796）。结论甘油三酯水平升高和高密度脂蛋白水平降低与脑血管功能受损密切相关，可能�Objective To understand the relationship between fipid levels and cerebral vessel hemodynamic comprehensive indexes （CVHI） in residents of communities and to provide the reference for research of stroke risk factors and stroke prevention. Methods A cross-sectional study was performed. From August to December of 2012, 5 153 residents （55 to 79 years old） were selected from 2 communities in Fengxian District by cluster sampling. CVHI and lipid levels of fasting venous blood were detected in baseline investigation. The CVHI score was calculated by unified method and the subjects were divided into two groups （〈75 points group and ≥ 75 points group） according to cut-off-point of CVHI score （75 points）. The lipid levels between two groups were compared and the relationship between lipid levels and CVHI scores was analyzed. Multivariate logistic regression analysis was conducted. Results Average age of participants were （64.23±6.40） years old and 2 209 （42.87%） were male and 2 944 （57.13%） were female. Triglyceride level （TG） in CVHI score 〈75 points group was significantly higher than that of the score t〉 75 points group for males and females （P〈0.01）. There was no significant difference of serum total cholesterol （TC） levels between two groups （P〉0.05）. LDL-C level in CVHI score below 75 points group was significantly higher than that of CVHI score t〉 75 points group in females （65-69 years old） P〈0.05, and there were no significant differences of LDL-C levels among other age groups （P〉0.05）. HDL-C level in CVHI score 〈75 points group was significantly lower than those in the score t〉75 points group for males and females （P〈0.01）. Multivariate logistic regression analysis indicated that HDL-C was protective factor for low CVHI score. Age, history of hypertension, diabetes, over-weight or obese, left ventricle thickness, arterial fibrillation, male and TG were risk factors for low CVHI score. The values of odds ratio （OR） and 95% confi

关 键 词：血脂 血流动力学 脑血管 危险因素 

分 类 号：R743[医药卫生—神经病学与精神病学]