放射介入联合微波消融在转移性肝癌治疗中的应用  

Radiological Intervention Combined Microwave Ablation in the Treatment of Metastatic Liver Cancer

作　　者：徐兴明[1] 滕红[1] 谢英[1] 赵张平[1] 陈建勋[1] 

机构地区：[1]四川省攀枝花市中心医院放射科,攀枝花617067

出　　处：《中国医药导刊》2015年第9期868-869,872,共3页Chinese Journal of Medicinal Guide

基　　金：四川省卫生厅课题立项(课题编号:100005);课题名称:放射介入联合微波消融在转移性肝癌治疗中的应用

摘　　要：目的：探讨采用放射性介入联合微波消融（MWA）治疗转移性肝癌的临床疗效,生存率及安全性评价。方法：选择本院肿瘤外科2010年12月~2011年12月收治的120例转移性肝癌患者,随机分为两组各60例;对照组予超声经皮MWA治疗,联合全身化疗;观察组采用放射介入肝动脉栓塞（TACE）化疗（给予丝裂霉素）治疗,并给予超声经皮MWA治疗;同时给予全身化疗,具体化疗方案与对照组相同。所有患者均于术后2周行彩超、CT或MRI评价消融效果。每3个月复查CT或MRI,比较两组的肿块3个月后的复发率。同时观察患者6个月~3年的生存率。并且观察术后两组的不良反应发生率。结果：经治疗后,观察组的消融效果优于对照组（P〈0.05）;3个月后观察组的肿块复发率低于对照组（P〈0.05）;观察组及对照组的6个月、1年、2年、3年的生存率分别为：91.7%、81.7%、61.7%、20.0%及85.0%、76.7%、53.3%、11.7%,差异均具有统计学意义（P〈0.05）。两组均未见到明显的不良反应发生。结论：采用放射介入联合MWA在转移性肝癌治疗,同时配合全身化疗,临床疗效较高,肿块复发率较低,提高患者6个月、1年、2年、3年的生存率,安全性高。Objective： To investigate the clinical efficacy, survival rate and safety evaluation of radioactive interventional combined microwave ablation （MWA） in the treatment of metastatic liver cancer.Methods： 120 patients with metastatic liver cancer in Dec,2010-Dec,20tt were randomly divided into two groups,60 cases in each group;The control group was treated with pereutaneous MWA therapy combined with systemic chemotherapy.All patients were evaluated by color Doppler ultrasound,CT or MRI at 2 weeks after operation.Every 3 months after CT or MRI, the recurrence rate of the two groups was compared with that of the 3 groups.At the same time, the survival rate of the patients was observed for 6 months and 3 years. And the incidence of adverse reactions in the two groups were observed.Results：After treatment, the observation group was better than the control group（P〈0.05）; the recurrence rate of tumor was lower than that of the control group（P〈0.05）.The survival rates of the observation group and the control group were 6 months, I yrs,2 yrs,3 yrs, 91.7%,81.7%,61.7%,20%,and 85%,76.7%, 53.3%, 11.7% respectively, and the difference was statistically significant（P〈0.05）. No obvious adverse reactions occurred in the two groups.Conclusion：Combined with systemic chemotherapy,radi otherapy combined with M WA in the treatment of metastatic liver cancer, with high clinical efficacy, low recurrence rate,improve patients 6 months,1 yrs,2 yrs,3 yrs survival rate.

关 键 词：转移性肝癌 放射介入肝动脉栓塞 超声经皮微波消融 疗效 

分 类 号：R735.7[医药卫生—肿瘤]