富血小板血浆修复根分歧病变的临床应用研究  

Clinical application research of platelet-rich plasma in the treatment of bifurcation involvement

作　　者：闫利勇[1] 张丽[1] 肖长杰[1] 

机构地区：[1]泰安市中心医院口腔科,山东271000

出　　处：《社区医学杂志》2015年第17期1-4,共4页Journal Of Community Medicine

基　　金：山东省医药卫生科技发展计划项目(2011QW027)

摘　　要：目的采用不同方法提取富血小板血浆(platelet-rich plasma,PRP),研究其作为自身复合生长因子来源的可行性,并探讨其在修复根分歧病变中的作用。方法选择2013年7月—2014年10月收治的18例慢性牙周炎合并根分叉患者作为研究对象,随机分为对照组、实验A组、实验B组各6例。对照组给予单纯引导组织再生(guided tissue regeneration,GTR)治疗,实验A组在对照组的基础上联合Anitua法获得的PRP治疗,实验B组在对照组的基础上联合Landesberg法获得的PRP治疗。比较三组治疗前及治疗后6、12个月牙周探诊深度(probing depth,PD)、临床附着丧失(clinical attachment loss,CAL)、临床附着获得情况。计量资料采用方差分析,两两比较采用LSD-t检验,P<0.05为差异有统计学意义。结果治疗后6、12个月,对照组、实验A组、实验B组PD及CAL[(3.35±1.61)、(2.40±0.61)、(1.98±0.56)、(4.45±0.71)、(3.18±0.75)、(3.09±0.48)、(3.88±2.15)、(2.62±0.73)、(1.92±0.54)、(3.91±0.61)、(3.30±0.88)、(2.85±0.58)mm]均较治疗前[(4.93±1.68)、(5.11±1.24)、(5.23±1.34)、(5.78±1.53)、(5.30±1.45)、(5.43±1.23)mm]降低,差异均有统计学意义(均P<0.05)。治疗后6、12个月,实验A组、实验B组PD及CAL均低于对照组,差异均有统计学意义(均P<0.05)。治疗后6、12个月,实验A组、实验B组临床附着获得分别为(2.27±1.40)、(2.20±1.44)、(2.60±2.29)、(2.76±0.87)mm,均高于对照组的(1.34±1.12)、(1.47±1.34)mm,差异均有统计学意义(均P<0.05)。结论 PRP对根分歧病变的修复具有促进作用,可显著降低患者PD及CAL,值得临床推广应用。Objective Using different methods to extract platelet- rich plasma（PRP） and observe its effects on the repairment of bifurcation involvement.Methods 18 case with chronic periodontitis and root bifurcation lesions from July 2013 to October 2014 were selected and randomly divided into control group,experimental group A and experimental group B（n=6）.The control group was treated with guided tissue regeneration（GTR）.The PRP obtained with Anitua method was used for the experimental group A therapy on the basis of the control group,and PRP acquired with Landesberg method was used for the experimental group B on the basis of the control group.To evaluate the probing depth（PD）,clinical attachment loss（CAL） and clinical attachment before treatment and6,12 months after therapy.Measurement data were processed by ANOVA,between group pairwise comparison was performed with LSD- t test,P〈0.05 was considered statistically significant.Results The PD and CAL of control group,experimental group A and experimental group B after 6 and 12 months [（3.35±1.61）、（2.40±0.61）、（1.98±0.56）、（4.45±0.71）、（3.18±0.75）、（3.09±0.48）、（3.88±2.15）、（2.62±0.73）、（1.92±0.54）、（3.91±0.61）、（3.30±0.88）、（2.85±0.58）mm] lower than that before treatment [（4.930±1.682）、（5.106±1.235）、（5.230±1.344）、（5.782±1.525）、（5.300±1.449）、（5.433±1.233）mm],the differences were statistically significant（all P〈0.05）.The PD and CAL of experimental group A and experimental group B after 6 and 12 months lower than that of the control group,the differences were statistically significant（all P〈0.05）.The clinical attachment of experimental group A and experimental group B after 6 and 12 months were（2.27±1.40）、（2.20±1.44）、（2.60±2.29）、（2.76±0.87）mm,higher than that of the control group [（1.34±1.12）、（1.47±1.34）mm],the differences were statistically significant（all P〈0.05）.Conclusion PRP has the p

关 键 词：富血小板血浆 生长因子 根分歧病变 

分 类 号：R781.4[医药卫生—口腔医学]