电纺制备布洛芬纳米纤维状固体分散体  

Preparation of ibuprofen nanofibers solid dispersion by electrospinning

作　　者：陆丽婷[1] 唐珊珊[1] 陈光[1] 苏瑛杰[1] 

机构地区：[1]吉林农业大学生命科学学院,长春130118

出　　处：《功能材料》2015年第17期17149-17152,共4页Journal of Functional Materials

基　　金：吉林省科技发展计划资助项目(20120303045ZY)

摘　　要：以水难溶性药物布洛芬(IB)为模型,聚氧化乙烯(PEO)与玉米淀粉(ST)为载体,利用高压静电纺丝的方法制备固体分散体。利用扫描电镜观察到纳米纤维成连续三维立体网状结构。红外光谱分析表明,IB、PEO和ST三者之间能够通过氢键相互作用。X射线衍射分析结果表明,含有少量药物时IB是以无定形或分子状态高度分散于聚合物中,增大药物含量时,会有少量晶体析出。体外溶出试验结果表明,载药纳米纤维状固体分散体载药量越大,释放时间越长。而载药量相同,纤维状纳米固体分散体中淀粉质量分数越大,释药速率越大,释放时间越短。The nanofibers loaded with slightly soluble drug-ibuprofen(IB)as solid dispersion were prepared by electrospinning technology with poly ethylene oxide(PEO)and corn starch(ST)as the carrier.A three-dimensional continuous network structure of the nanofibers was observed by scanning electronic microscopy.The hydrogen bonding interactions among IB,PEO and ST were demonstrated by infrared spectroscopy.The results of X-ray diffraction suggested that IB was highly distributed in the nanofibers at an amorphous status or a molecular state when the drug content was small.There will appear some crystal precipitation when the drug content increases.The results of in vitro dissolution test showed that when the drug content of nanofiber increased,the release time of IB will longer.When the drug content was constant,along the ST content increase,the release rate will increase and the release time will decrease.

关 键 词：布洛芬 聚氧化乙烯 玉米淀粉 静电纺丝 固体分散体 

分 类 号：Q71[生物学—分子生物学]