B7-H3和B7-H4在鼻咽癌组织中的表达及意义  

Expression and Clinical Significance of B7-H3 and B7-H4 in Nasopharyngeal Carcinoma

作　　者：郑大勇[1] 董少婷[1] 陈锦章[1] 吕成伟[1] 黄振华[1] 黄娜[1] 何本夫[2] 石敏[1] 

机构地区：[1]南方医科大学南方医院肿瘤内科,510515 [2]解放军第421医院,510318

出　　处：《实用癌症杂志》2014年第6期617-619,共3页The Practical Journal of Cancer

基　　金：广东省科技计划项目(编号:2012B031800480)

摘　　要：目的探讨B7-H3和B7-H4基因突变在鼻咽癌中的表达及临床意义。方法以60例鼻咽癌标本作为病例组,以30例正常子鼻咽部组织作为对照组,应用免疫组织化学技术,检测两组中B7-H3和B7-H4的表达。结果 B7-H3和B7-H4在鼻咽癌组织中阳性率均明显高于正常鼻咽组织,差异均有显著统计学意义(P<0.01);Ⅲ+Ⅳ期及淋巴结转移患者B7-H3和B7-H4阳性率分别明显高于Ⅰ+Ⅱ期、无淋巴结转移患者,差异有明显的统计学意义(P<0.05)。结论 B7-H3和B7-H4与鼻咽癌发生和发展密切相关。Objective To study the expression and clinical significance of B7-H3 and B7-H4 in nasopharyngeal carcinoma. Methods 60 cases of endometrial carcinoma was the case group,and 70 cases of normal endometrial was the control group.The expressions of B7-H3 and B7-H4 in the 2 groups were analyzed by immunohistochemisty. Results The positive rates of B7-H3 and B7-H4 in nasopharyngeal carcinoma were significantly higher than those of normal nasopharyngeal tissues,the differences were statistically significant( P < 0. 01); positive rates of B7-H3 and B7-H4 in stage Ⅲ and Ⅳ and lymph node metastasis patients were significantly higher than those of stage Ⅰ and Ⅱ and without lymph node metastasis patients,the differences were statistically significant( P < 0. 05). Conclusion B7-H3 and B7-H4 are closely related with the carcinogenesis and progression of nasopharyngeal carcinoma.

关 键 词：B7-H3基因 B7-H4基因 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]