子宫内膜癌组织中基因及分子标志物表达及其与预后的相关性研究  

Study on the correlation between the expression of ER, PR, p53 and Ki-67 in endometrial carcinoma and clinical prognosis

作　　者：周惠玲[1] 何莹莹[1] 范良生[1] 邓志校[1] 张晓薇[1] 

机构地区：[1]广州医科大学附属第一医院妇产科,广东广州510120

出　　处：《中国实用妇科与产科杂志》2015年第10期947-950,共4页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨子宫内膜癌组织中雌激素受体(ER)、孕激素受体(PR)、p53抑癌基因(p53)、抗原Ki-67(Ki-67)的表达及与临床预后之间的关系。方法选取2009—2014年广州医科大学附属第一医院妇科收治的79例子宫内膜癌患者的癌组织标本,采用免疫组化法检测其中ER、PR、p53、Ki-67的蛋白表达情况。结果 79例子宫内膜癌病例中,ER、PR、p53、Ki-67阳性表达率:87.3%、88.6%、84.8%、79.7%;ER的蛋白表达与患者预后有关;PR与病理类型、肌层浸润、组织分化有关;p53与组织分化有关;Ki-67与临床分期、淋巴转移有关(均P<0.05)。ER与PR的表达、p53与Ki-67的表达均呈正相关(P<0.05)。结论 ER、PR、p53、Ki-67的联合检测可能作为子宫内膜癌发生、发展及临床转移的生物学指标及作为判断子宫内膜癌恶性程度及评估预后的分子标志物,其具体作用机制值得进一步研究。Objective To investigate the relationship between the expression of ER ,PR, p53 and Ki-67 in endometrial carcinoma and clinical prognosis. Methods The 79 clinical patients who sought medical advice at the First Affiliated Hospital of Guangzhou Medical University from 2009-2014 were included. Expression of ER, PR, p53 and Ki-67 were detected by immunohistochemical SP method respectively in the 79 cases of endometrial carcinoma. Results The positive expression rates of ER, PR, p53 and Ki-67 were 87.3%, 88.6%, 84.8% and 79.7% in endometrial carcinoma respec- tively.The expression of ER was related to the prognosis of the patients. The expression of PR was related to pathological type, muscle invasion, histologic classification. The expression of p53 was related to histologic classification. The expression of Ki-67 was related to clinical stage and lymphatic metastasis. Expression of ER was positively correlated with expression of PR. Expression of p53 was positively correlated with expression of Ki-67 （P 〈 0.05）. Conclusions ER, PR, p53 and Ki-67 have significant impacts on the development of endometrial carcinoma. The expressions of combined detection of them can be used as an important indicator to diagnose endometrial carcinoma and clinical metastasis. As a molecular marker, it is also a necessary basis for evaluating the degree of malignancy and prognosis. However, further research should be made on its mechanism.

关 键 词：子宫内膜癌 雌激素受体 孕激素受体 P53抑癌基因 抗原Ki-67 免疫组织化学 

分 类 号：R737.3[医药卫生—肿瘤]