胃癌组织微环境中调节性T细胞的状况与预后的关系  

The Relationship Between Regulatory T Cells and Prognosis in the Microenvironment of Gastric Cancer

作　　者：潘武[1] 牛万成[2] 陈复兴[3] 徐正元[1] 刘振峰[1] 

机构地区：[1]江苏沭阳县人民医院消化内科,223600 [2]解放军第97医院普外科,徐州221004 [3]解放军第97医院实验科,徐州221004

出　　处：《中国继续医学教育》2015年第26期67-68,共2页China Continuing Medical Education

摘　　要：目的观察胃癌患者肿瘤、瘤旁、正常胃壁组织Treg细胞状况,分析其与预后的关系。方法采用免疫组织化学方法检测50例胃癌手术患者肿瘤、瘤旁1 cm、正常胃壁组织中Treg细胞密度。结果肿瘤组织及其癌旁组织中Treg细胞的平均浸润数目高于正常组,P<0.05,差异具有统计学意义,肿瘤组织内Treg细胞与胃癌预后有关系,P<0.05,差异具有统计学意义。结论胃癌组织微环境中Treg细胞的含量明显升高,且肿瘤组织内Treg细胞的含量是胃癌患者的独立预后因素。Objective To observe the relationship between regulatory T cells in tumor, paratumor and normal tissues and prognosis of gastric cancer. MethodsThe density of treg cells was detected by immunohistochemical method with tumor, pefitumoral 1 cm and normal tissues in 50 cases of gastric cancer patients.Results The average number of inifltration of treg cells in cancer tumor and its surrounding tissues was higher than that of normal gastric tissues,P〈0.05, had difference statistically significance, there was an obvious correlation between treg cells in tumor tissues and the prognosis of gastric cancer,P〈0.05, had difference statistically signiifcance. ConclusionTreg cells in tissue microenvironment were significantly increased, and the content of treg cells in tumor was the independent prognostic factor of gastric cancer patients.

关 键 词：组织微环境 调节性T细胞 细胞因子 

分 类 号：R735.2[医药卫生—肿瘤]