PSMA6基因rs17458312位点多态性与脑梗死的相关性研究  

Association of rs17458312 Polymorphism of PSMA6 Gene with Cerebral Infarction

作　　者：赵西耀[1] 何芳梅[2] 

机构地区：[1]浙江大学医学院附属第二医院建德分院神经内科,浙江建德市311600 [2]西安医学院第一附属医院神经内科,陕西西安市710077

出　　处：《中国康复理论与实践》2015年第9期1091-1094,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：陕西省教育厅专项科研计划项目(No.2010JK803)

摘　　要：目的探讨中国汉族人群中PSMA6基因rs17458312(-1520C/T)位点的多态性与脑梗死的相关性。方法对211例脑梗死患者(病例组)和201例健康体检者(对照组),应用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)检测PSMA6基因rs17458312位点单核苷酸多态性,并分析其基因型及等位基因频数的分布。结果 CC、CT、TT基因型频率及C等位基因频率在两组中分布无显著性差异(P>0.05)。性别分层后,各亚组各基因型及等位基因频率分布也无显著性差异(P>0.05)。结论 PSMA6基因rs17458312位点可能与脑梗死的发病无关。Objective To evaluate the association between rs17458312（-1520C/T） polymorphism of PSMA6 gene and cerebral infarction in Chinese Han population. Methods 211 cerebral infarction patients（case group） and 201 healthy controls（control group） were selected in the study. The single nucleotide polymorphism of rs17458312 of PSMA6 gene was identified with the polymerase chain reaction（PCR） and restriction fragment length polymorphism（RFLP）. The genotypes and allele frequencies distributed in cerebral infarction patients and healthy controls were analyzed. Results The frequencies of CC, CT, TT genotypes and the C allele all revealed no significant difference between the case group and the control group（P〈0.05）. After stratified by genders, the difference among all genetypes and alleles weren＇t significant between subgroup（P〈0.05）. Conclusion The rs17458312 of PSMA6 gene might not be associated with the cerebral infarction.

关 键 词：PSMA6基因 单核苷酸多态性 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]