氨基四氮唑类化合物合成研究进展  

The Synthesis Development of Aminotetrazoles

作　　者：王文慧[1] 郭冬艳[1] 蒋筱莹 谢媛媛[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310014

出　　处：《浙江化工》2015年第9期15-18,共4页Zhejiang Chemical Industry

摘　　要：虽然尚未在天然产物中发现,但许多的氨基四氮唑类化合物都具有生物活性,如抗过敏、抗病毒、抗炎、抗肿瘤等活性。综述了氨基四氮唑类化合物的几种有代表性的合成方法,并对合成方法进行了分析总结。Although tetrazole and its derivatives rarely occur in nature, the vast majority of all show the biological activity. 5-Aminotetrazoles show anti-allergic and anti-asthmatic, antiviral and anti-inflammatory, antineoplastic activities. This article summarized some representative synthetic methods of the aminotetrazoles and reviewed the advantages and disadvantages of these methods.

关 键 词：氨基四氮唑类化合物 化学合成 电环化反应 

分 类 号：R914.5[医药卫生—药物化学]