高血压脑出血患者ET-1、TNF-α及NO水平变化及其相关性  

ET-1,TNF-αand NO Levels in Patients With Cerebral Hemorrhage and Its Correlation

作　　者：张俊士[1] 常娜[1] 贺维亚[1] 

机构地区：[1]河南大学淮河医院神经内科,475000

出　　处：《中国卫生标准管理》2015年第26期22-23,共2页China Health Standard Management

摘　　要：目的：研究高血压脑出血患者血内皮素（ET-1）、脑肿瘤坏死因子（TNF-α）及一氧化氮（NO）水平变化及其相关性。方法选择2013年12月~2014年12月来我院治疗脑出血的患者100例，分为单纯脑出血组、高血压脑出血组、每组各50例，同期选择50例健康体验者作为对照组，对三组的ET-1、TNF-α、NO情况进行对比。结果通过调查发现，高血压脑出血组患者的ET-1、TNF-α水平明显高于其他两组，差异显著（P＜0.05），高血压脑出血组患者的NO水平明显低于其他两组，差异显著（P＜0.05）。结论通过本研究可以发现，高血压脑出血、单纯脑出血组的ET-1、TNF-α水平均明显提高，NO水平下降，以高血压脑出血变化更大，由此可以将ET-1、TNF-α、NO水平作为判断高血压脑出血的指标，为临床诊断高血压脑出血提供新的思路。Objective To study hypertensive cerebral blood endothelin （ET-1） hemorrhage, brain tumor necrosis factor （TNF-α） and nitric oxide （NO） levels in their relationship.MethodsFrom December 2013 to December 2014,100 cases of patients in our hospital with intracerebral hemorrhage, cerebral hemorrhage were randomly divided into simple cerebral hemorrhage group and hypertensive cerebral hemorrhage group, 50 cases of patients in each group. Select 50 cases of health experience as control group over the same period. Compared the three groups’ ET-1, TNF-α, NO circumstances. Results The survey found that hypertensive patients with cerebral hemorrhage group ET-1, TNF-α levels were significantly higher than the other two groups, the difference was significant （P〈0.05）, NO levels of hypertensive intracerebral hemorrhage patients was significantly lower than the other two group, the difference was significant （P〈0.05）. Conclusion Through the study, we can find that cerebral hemorrhage, cerebral hemorrhage alone group ET-1, TNF-α levels are significantly increased, NO levels decrease, the greater the change in hypertensive intracerebral hemorrhage, so ET-1 , TNF-α, NO levels can be as judged by hypertensive cerebral hemorrhage index, provide new ideas for clinical diagnosis of hypertension cerebral hemorrhage.

关 键 词：高血压脑出血 单纯脑出血 ET-1 TNF-Α NO 

分 类 号：R743.34[医药卫生—神经病学与精神病学]