结肠癌中RECK的表达和临床相关性研究  

Expression of RECK in colorectal cancer and its' clinical significance

作　　者：陈现亮[1] 吴义娟[1] 吕卓[1] 赵慧敏[1] 韩宝娟[1] 

机构地区：[1]河北医科大学附属邢台人民医院消化内科,河北邢台054000

出　　处：《中国中西医结合消化杂志》2015年第9期612-614,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：邢台市科技支撑计划项目(No:2014ZC157)

摘　　要：[目的]研究RECK在结肠癌及正常肠组织中的表达,探讨RECK在结肠癌的发生、发展、浸润和转移中的作用。[方法]应用免疫组织化学法(SABC)检测104例结肠癌和20例正常结肠黏膜组织中RECK基因的表达。[结果]RECK在结肠癌中的阳性表达率为65.38%,低于在正常结肠黏膜组织中的表达(100%)(P<0.05),并随肿瘤临床Dukes分期的提高、淋巴结转移及肿瘤分化程度的降低而降低(P<0.05)。[结论]结肠癌组织中RECK呈低表达,检测RECK的表达对结肠癌的诊断、治疗和预后的判断有重要意义。[Objective] To study the expression of reversion-inducing cysteine-rich protein with Kazal motifs（RECK）in eolorectaI cancer and normal eolorectal mucosa, and to probe the role in colorectal carcino ma. [Methods]Immunochemical staining was used to detect the expression of RECK protein in 104 cases of coloreetal carcinoma and 20 cases of normal coloreetal mucosa. [Results]The expression of RECK in color- ectal carcinoma was significantly lower（65.38 % ）than that in normal colorectal mucosa（ 100 G ）（P〈0.05）, and reduced with the decreased histological differentiation, the increased Dukes stages and occurrence of lymphatic（P〈0.05）. EConclusion-]RECK is lowly expressed in eoloreetal carcinoma. RECK play important roles in the infiltration and metastasis in colorectal carcinoma. Detection of RECK may be used in prognosis judgement of colorectal carcinoma.

关 键 词：RECK 结肠癌 

分 类 号：R735.3[医药卫生—肿瘤]