益生菌治疗轻中度溃疡性结肠炎的疗效观察  

Probiotics in treatment of mild-moderate ulcerative colitis efficacy

作　　者：张诒凤 张豹[1] 崔姗姗[1] 张汝建[2] 

机构地区：[1]泰山医学院,山东泰安271016 [2]泰山医学院附属医院,山东泰安271000

出　　处：《泰山医学院学报》2015年第6期604-607,共4页Journal of Taishan Medical College

摘　　要：目的：观察双歧杆菌三联活菌联合美沙拉嗪治疗轻、中度溃疡性结肠炎的临床疗效。方法选择本院2013年1月~2014年9月门诊及住院的符合轻中度溃疡性结肠炎诊断标准的患者共56例。随机分为对照组及治疗组。对照组26例单独给予美沙拉嗪肠溶片治疗，治疗组30例给予双歧杆菌三联活菌胶囊和美沙拉嗪肠溶片治疗，均连续治疗8周。观察两组治疗后疗效、C 反应蛋白变化及不良反应发生情况。结果治疗组完全缓解15例，好转13例，无效2例，有效率93.3%，对照组完全缓解6例，好转10例，无效10例，有效率61.5%。治疗组临床疗效显著优于对照组，临床症状评分、UC - DAI 及内镜下评分变化较对照组更为显著（ P 〈0.05）。结论双歧杆菌三联活菌联合美沙拉嗪肠溶片治疗轻、中度溃疡性结肠炎较单独应用美沙拉嗪临床疗效更好，且患者耐受性较好，不良反应少，能降低溃疡性结肠炎的复发率。Objective：To observe the clinical effect of Bifidobacterium triple June viable combined with mesalazine on mild - moderate active ulcerative colitis. Methods：To select 56 outpatient and inpatient who accord with the standard of di-agnosis of mild - moderate ulcer colitis from January 2013 to June 2014. Dvided them into treatment group and control group randomly. The 30 cases in treatment group were given the bifidobacterium triple viable and mesalazine enteric coated tablets treatment. The 26 cases in the control group were given the mesalazine enteric coated tablets treatment separately,they both had been treated for 8 weeks. Observed the treatment efficacy of the two groups,c - reactive protein change and adverse re-actions. Results：In the treatment group,15 cases were in remission completely,13 cases were improved,2 cases were in-effective,the efficiency was 93. 3%. In control group ,6 cases were in remission completely,10 cases were improved,10 cases were ineffective,efficiency was 61. 5%. The clinical effect of treatment group was significantly better than the control group,clinical symptoms score,UC - DAI score and endoscopic changed more than control group significantly（P 〈 0. 05） . Conclusions：The curative effect that Bifidobacterium capsules combined with mesalazine enteric coated tablets in the treat-ment of mild - moderate ulcerative colitis is better than that of single application of mesalazine,and it was well tolerated in patients with less adverse reaction,it could reduce the rate of recurrence of ulcerative colitis.

关 键 词：溃疡性结肠炎 双歧杆菌三联活菌 美沙拉嗪 

分 类 号：R574.62[医药卫生—消化系统]