紫杉醇、草酸铂、替吉奥联合治疗晚期胃癌的临床观察  

Paclitaxel oxaliplatin S-1 combination regimen in treatment of advanced gastric cancer

作　　者：舒阳春[1] 李玉齐[1] 杨曙[1] 刘魁凤[1] 

机构地区：[1]广东药学院附属第一医院肿瘤科,广东广州510080

出　　处：《泰山医学院学报》2015年第6期618-620,共3页Journal of Taishan Medical College

摘　　要：目的：观察紫杉醇/草酸铂/替吉奥方案治疗晚期胃癌的疗效和不良反应。方法晚期胃癌患者30例，接受紫杉醇/草酸铂/替吉奥方案化疗。紫杉醇135 mg/m2第1天，草酸铂100 mg/m2第1天，替吉奥体表面积1.25~1.5 m2给予50 mg bid；体表面积〉1.5 m2给予60 mg bid；d1~14，21天为1疗程，至少治疗2个疗程。结果完全缓解0例，部分缓解16例，稳定12例，进展3例，总有效率50.0%，中位疾病进展时间（TTP）5.5个月，中位生存时间（MST）11.8个月。主要不良反应为骨髓抑制，胃肠道反应和外周神经毒性，Ⅲ＋Ⅳ度白细胞下降36.6%，其余多为Ⅰ~Ⅱ度毒性反应。结论紫杉醇/草酸铂/替吉奥方案治疗晚期胃癌，有较好的疗效，毒性可以耐受。Objective：To evaluate the results of combinafiom chemotherapy with paclitaxel,oxaliplatin,S - 1 in the treatment of advanced gastric cancer. Methods：thirty patients of advanced gastric cancer were treated with paclitaxel,oxali-platin and S - 1 combination regimen. paclitaxel 135mg/ m2 d1,oxaliplatin 100mg/ m2 d1,S - 1（doses based on patient’s body surface area ：1. 25 ~ 1. 5m2 ,50mg bid;〉 1. 5 m2 ,60 mg bid,d1 - 14. Three weeks repeated Results The overall re-sponse rate was 50. 0% ,the median time to progression was 5. 5 months. median survival time 11. 8 months. The main tox-icity was myelosuppression,nausea and vomitimg,peripheral nerotixicity Conclusion：paclitaxel,oxaliplatin ,and S - 1 comi-nation regimen has good anti - tumor activity and good toleration on patients with advanced gastric cancer.

关 键 词：紫杉醇 草酸铂 替吉奥 胃癌 化疗 

分 类 号：R735.2[医药卫生—肿瘤]