小剂量顺铂动脉化疗联合放疗对中晚期宫颈癌的临床疗效  

Different Doses of Cisplatin for Arterial Chemotherapy Combined with Radiotherapy in Advanced Cervical Cancer

作　　者：张晓峰[1] 李凤霜[2] 范晓芬[1] 王卉[1] 袁赟[1] 

机构地区：[1]首都医科大学附属北京妇产医院放射科,北京100026 [2]首都医科大学附属北京妇产医院妇瘤科,北京100026

出　　处：《现代生物医学进展》2015年第23期4505-4508,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30672254)

摘　　要：目的：探讨小剂量顺铂用于子宫动脉化疗联合放疗治疗中晚期宫颈癌的临床疗效。方法：选择2010年8月~2012年8月我院收治的中晚期宫颈癌患者75例,根据不同治疗方案将其分为单纯放疗组25例（单纯采用放疗治疗）、小剂量动脉化疗组25例（同时放化疗,顺铂周疗的剂量控制在20 mg·m-2）及标准剂量静脉化疗组25例（同时放化疗,顺铂周疗的剂量控制在40 mg·m-2）。观察并比较三组患者的临床疗效、两年生存率及毒性反应发生情况等。结果：小剂量动脉化疗组与标准剂量静脉化疗组的总有效率及两年生存率显著高于单纯放疗组（P〈0.05）,小剂量动脉化疗组的总有效率和两年生存率高于标准剂量静脉组,差异具有统计学意义（P〈0.05）。单纯放疗组及小剂量动脉化疗组的毒性反应发生率显著低于标准剂量静脉组（P〈0.05）;单纯放疗组与小剂量动脉化疗组患者的毒性反应发生率对比无统计学差异（P〉0.05）。结论：小剂量顺铂动脉化疗可以有效降低中晚期宫颈癌患者的急性毒性反应,值得临床进一步推广应用。Objective： To investigate the clinical efficacy of low-dosed cisplatin in chemotherapy and radiotherapy on the treatment of the advanced cervical cancer. Methods： 75 patients with advanced cervical cancer who were treated in our hospital from August 2010 to 2012 were selected. According to the different treatment methods, the patients were divided into the radiotherapy group（25 cases who were treated with radiotherapy）, the low-dosed group（25 cases who were treated with 20 mg·m-2cisplatin in chemotherapy and radiotherapy） and the standard-dosed group（25 cases who were treated with 40 mg·m-2cisplatin in chemotherapy and radiotherapy）. Then the toxic reaction, clinical effect and the two-years＇ survival rate in the three groups were observed and compared.Results： The total effective rate and survival rate of the low-dosed group and the standard-dosed group were significantly higher than those of the radiotherapy group（P〈0.05）; The curative effect rate and the survival rate of low-dosed group were higher than those of the standard-dosed group, and the differences were statistically significant（P〈0.05）. The toxicity reaction of the radiotherapy group and the low-dosed group were significantly lower than that of the standard-dosed group（P〈0.05）; There was no statistically significant about the toxicity reaction between the radiotherapy group and the low-dosed group（P〉0.05）. Conclusion： Low dose cisplatin can reduce the toxicity reactions of patients with advanced cervical cancer, and improve the curative effect and survival rate, which is worthy of clinical application.

关 键 词：动脉化疗 中晚期宫颈癌 小剂量顺铂 放疗 

分 类 号：R737-33[医药卫生—肿瘤]