RegIV和CCL7在胃癌中的表达及相关性分析  

Expressions and Correlation Analysis of RegIV and CCL7 in Gastric Cancer

作　　者：严伟 徐细明[1] 汤俊[1] 来旭[1] 赵涓涓 

机构地区：[1]武汉大学人民医院肿瘤中心,湖北武汉430060

出　　处：《现代生物医学进展》2015年第26期5063-5066,共4页Progress in Modern Biomedicine

摘　　要：目的：研究再生基因4（Reg IV）和趋化因子CCL7在胃癌中的表达及相关性。方法：选择2010年3月至2014年3月在我院接受手术治疗的胃癌患者72例作为研究对象。对比Reg IV及CCL7在胃癌组织以及癌旁正常组织中的阳性表达情况,分析不同病理参数对Reg IV及CCL7阳性表达的影响,Reg IV与CCL7表达的相关性及影响Reg IV及CCL7在胃癌中表达的危险因素。结果：胃癌组织的Reg IV阳性率及CCL7阳性率均显著高于癌旁正常组织,差异均有统计学意义（均P〈0.05）。有浆膜浸润、有淋巴结转移以及TNM分期为Ⅲ~Ⅳ期者的Reg IV与CCL7阳性表达率均显著高于无浆膜浸润、无淋巴结转移以及TNM分期为0~Ⅱ期者,差异均有统计学意义（均P〈0.05）。经Spearman法分析相关性可知,Reg IV与CCL7表达呈正相关。根据Logistic回归分析法可知,有浆膜浸润、有淋巴结转移以及TNM分期为Ⅲ~Ⅳ期均为Reg IV及CCL7在胃癌中表达的危险因素。结论：Reg IV与CCL7均可在胃癌组织中呈现出较高的阳性表达,且二者与患者临床预后有密切关系,在临床治疗过程中值得关注与重视。Objective： To study the expressions and correlation of regenerating islet-derived family member 4 （RegIV） and CCL7 in gastric cancer. Methods： Selected 72 gastric cancers who were underwent operation in our hospital from March 2010 to March 2014 as the research object. Compared the positive expression rates of ReglV and CCL7 between in gastric cancer tissues and in pericarcinoma normal tissues, analyzed the influence of different pathological parameters on the positive expression of ReglV and CCL7, and the corre- lation between the expression of RegIV and CCL7, to found out the risk factors for the expression of ReglV and CCL7 in gastric cancer. Results： The positive expression rates of ReglV and CCL7 in gastric cancer tissues were significantly higher than pericarcinoma normal tissues, the differences were statistically significant（P〈0.05）. The positive expression rates of ReglV and CCL7 in cancers with serosal in- vasion, lymph node metastasis and TNM stage III ~ 1V were significantly higher than those cancers without serosal invasion, lymph node metastasis and TNM stage 0- II ,all the differences were statistically significant （P〈0.05）. Spearman correlation analysis showed, the expression of ReglV positively correlated with CCL7. And according to the Logistic regression analysis,with serosal invasion, lymph node metastasis and TNM stage III-IV were the risk factors for the expressions of RegIV and CCL7 in gastric cancer. Conclusion： The positive expression rates of ReglV and CCL7 in gastric cancer are very high, and they have a close relationship with the clinical prognosis, which need to be paid more attention during the clinical treatment.

关 键 词：REG IV CCL7 胃癌 表达 相关性分析 

分 类 号：R735.2[医药卫生—肿瘤]