血清干扰素γ、肿瘤坏死因子α、白细胞介素10在溃疡性结肠炎中的水平变化及其与幽门螺杆菌感染的相关性  

The changes of serum IFN -gamma,TNF alpha and IL -10 levels in ulcerative colitis and its relevance to helicobacter pylori infection

作　　者：叶咸德 颜小丹[2] 

机构地区：[1]宁波明州医院消化内科,浙江省宁波315100 [2]浙江省台州医院消化内科

出　　处：《中国基层医药》2015年第18期2790-2792,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨血清干扰素γ（IFN-γ）、肿瘤坏死因子α（TNF-α）、白细胞介素10（IL-10）在溃疡性结肠炎（UC）中的水平变化及其与幽门螺旋杆菌（Hp）的相关性。方法选择80例 UC 患者为研究对象，80例 UC 患者中50例处于活动期，30例处于缓解期。50例 UC 活动期患者中：轻度14例，中度26例，重度10例。选择30名健康者为健康对照组。检测血清 IFN-γ、TNF-α、IL-10水平及 Hp 感染情况。结果活动期组血清 TNF-α、IL-10水平高于缓解期组和对照组，差异有统计学意义[（54．75±5．92）ng／L 比（23．69±4．15）ng／L与（20．45±4．01）ng／L，F ＝36．79，P ＝0．000；（35．16±6．72）ng／L 与（25．12±5．37）ng／L 与（23．96±5．21）ng／L，F ＝35．68，P ＝0．000]，活动期组血清 IFN-γ水平低于缓解期组和对照组，差异有统计学意义[（14．98±3．15）ng／L 与（26．06±4．31）ng／L 与（27．16±4．39）ng／L，F ＝35．68，P ＝0．000]。随着 UC 活动期患者病情的加重，TNF-α、IL-10水平呈升高趋势（F ＝32．81、24．95，均 P ＜0．05），IFN-γ呈降低趋势（F ＝22.29，P ＜0．05）。50例 UC 活动期患者中，18例 Hp 阳性，32例 Hp 阴性。UC 活动期组 Hp 阳性患者血清TNF-α、IL-10水平高于 Hp 阴性患者，差异有统计学意义（t ＝4．62、4．35，均 P ＜0．01），UC 活动期组 Hp 阳性患者血清 IFN-γ水平低于 Hp 阴性患者，差异有统计学意义（t ＝5．91，P ＜0．01）。结论UC 活动期患者 TNF-α、IL-10高表达，IFN-γ低表达，IFN-γ、TNF-α、IL-10的表达与 Hp 感染密切相关。Objective To study the changes of serum IFN -gamma,TNF alpha and IL -10 levels in ulcera-tive colitis and its relevance to helicobacter pylori infection.Methods 80 UC patients were selected as the research object,and 50 cases of 80 patients were in the activity stage of UC,30 patients were in remission.In the 50 patients with active UC：14 cases were mild,26 cases were moderate,and 10 cases were severe.30 healthy subjects were set as healthy controls.Detection of serum IFN -gamma,TNF alpha,IL -10 levels and Hp infection were made.Results The serum TNF alpha and IL -10 levels of the activity group were higher than those of the remission group and the control group,the difference was statistically significant[TNF alpha ：（54.75 ±5.92）ng/L vs.（23.69 ±4.15）ng/L vs.（20.45 ±4.01）ng/L,F =36.79,P =0.000;IL -10 ：（35.16 ±6.72）ng/L vs.（25.12 ±5.37）ng/L vs.（23.96 ± 5.21）ng/L,F =35.68,P =0.000],the serum IFN -gamma level of the activity group was lower than those of the remission group and the control group,the difference were statistically significant[（14.98 ±3.15）ng/L vs.（26.06 ± 4.31）ng/L vs.（27.16 ±4.39）ng/L,F =35.68,P =0.000].As the aggravating of patients with UC in activity stage,TNF alpha and IL -10 levels showed a trend of increase（F =32.81,24.95,all P 〈0.05）,while IFN -gamma showed a trend of reduce（F =22.29,P 〈0.05）.In 50 cases of active UC patients,18 patients with Hp positive, 32 cases were Hp negative.In active UC group Hp positive patients＇serum TNF alpha and IL -10 levels higher than the Hp negative patients,the difference was statistically significant（t =4.62,4.35,all P 〈0.01）.Serum levels of IFN-gamma of active UC patients with Hp positive group was lower than the Hp negative patients,the difference was sta-tistically significant（t =5.91,P 〈0.01）.Conclusion In active UC patients expression of TNF alpha and IL -10 are high,and IFN -gamma expression is low.The expression of IFN -gamma,TNF alpha and IL -10 are closely related to Hp infec

关 键 词：结肠炎 溃疡性 干扰素 γ 肿瘤坏死因子 α 白细胞介素10 螺杆菌 幽门 

分 类 号：R574.62[医药卫生—消化系统]