ER,PR,Her-2,P53在乳腺癌中的表达及其相关意义  

Expression of ER,PR,HER- 2 and P53 in breast cancer and their clinical significance

作　　者：项鹏程 白雪峰[1] 

机构地区：[1]包头市肿瘤医院病理科,内蒙古包头014030

出　　处：《包头医学院学报》2015年第9期3-4,80,共3页Journal of Baotou Medical College

摘　　要：目的:分析雌二醇受体(estradiol receptor,ER)、孕酮受体(progesterone receptor,PR)、人类表皮生长因子受体2(human epithelial growth factor receptor 2,Her-2)、P53在乳腺癌中的表达并探究其与临床病理学相关指标的相关性。方法:对包头肿瘤医院2008年1月至2013年12月收治的984例乳腺癌组织中ER、PR、Her-2、P53的表达情况进行统计并分析其与组织大小,组织类型、腋窝淋巴结转移情况的关系。结果:984例乳腺癌组织中ER的阳性率为64.0%(603/984),PR的阳性率为56.8%(559/984),Her-2的阳性率为24.9%(245/984),P53的阳性率为54.3%(534/984)。其中ER与PR结果相同,均与组织大小、组织类型有相关性(均为P<0.01),与淋巴结转移无相关性(P>0.05)。Her-2与组织大小、淋巴结转移、组织类型均有相关性(分别为P<0.05、P<0.05、P<0.01);P53与淋巴结转移有相关性(P<0.01),与组织大小、组织类型无相关性(均为P>0.05)。ER与PR表达成正相关(P<0.01),Her-2与P53表达成正相关(P<0.01),Her-2与ER、PR表达成负相关(P<0.01)。结论:Her-2和P53作为乳腺癌预后不良的重要指标与作为乳腺癌预后良好的重要指标ER、PR的表达呈负相关,与组织学分型及腋窝淋巴结转移状态有相关性,ER、PR与组织大小及组织学分型有相关性。Objective： To analyze and explore the expression of estradiol receptor（ ER）,progesterone receptor（ PR）,human epithelial growth factor receptor 2（ Her- 2） and P53 in breast cancer and their correlation with clinical pathological factors. Methods： 984 cases of breast cancer in Baotou Tumor Hospital from January 2008 to December 2013 were selected. Based on the expression of ER,PR,Her- 2 and P53 in breast cancer tissues of these patients,their correlation with the size and type of tissues and axillary lymph node metastasis was statistically analyzed. Results： Among all breast cancer tissues,the positive rate of ER,PR,Her- 2 and P53 was 64. 0%（ 603 /984）,56. 8%（ 559 /984）,24. 9 %（ 245 /984）,and 54. 3%（ 534 /984） respectively. The result of ER was the same to that of PR. Both of them had correlation with the size,type of the tissues（ P 〈0. 01）,and had no correlation with lymph node metastasis（ P 〈0. 05）. Her- 2 correlates with the size of the tissues,lymph node metastasis and the type of the tissues（ P 〈0. 05,P 〈0. 05,P 〈0. 01,respectively）; P53 correlates with lymph node metastasis（ P 〈0. 01） and had no correlation with the size and type of tissues（ P 〉0. 05）. The expression of ER and PR had positive correlation（ P 〈0. 01）,so did the expression of Her- 2 and P53（ P 〈0. 01）. There was negative correlation between the expression of Her- 2 and the expression of ER and PR（ P 〈0. 01）. Conclusion： As the important indicators of poor prognosis of breast cancer,Her- 2 and P53 are negatively correlated with the expression of ER and PR,the important indicators of good prognosis of breast cancer. Her- 2 and P53 correlates with histology subdivision and axillary lymph node metastasis,while ER and PR correlates with the size of tissue and histology subdivision.

关 键 词：雌二醇受体 孕酮受体 表皮生长因子受体2 P53 

分 类 号：R737.9[医药卫生—肿瘤]