DC-CIK联合化疗对中晚期食管鳞癌患者生命质量的影响及护理  

Effect of DC-CIK combined with chemotherapy on quality of life in patients with moderate and advanced esophageal squamous carcinoma and its nursing care

作　　者：杨红[1] 杨光[2] 张曙光[2] 

机构地区：[1]中国医科大学附属第一医院高压氧科,沈阳110001 [2]中国医科大学附属第一医院胸外科,沈阳110001

出　　处：《检验医学与临床》2015年第19期2827-2829,共3页Laboratory Medicine and Clinic

基　　金：国家自然科学青年科学基金资助项目(81201890);辽宁省自然科学基金资助项目(2013021002)

摘　　要：目的观察树突状细胞(DC)-细胞因子诱导的杀伤细胞(CIK)联合多西紫杉醇+顺铂化疗(DC方案)对中晚期食管鳞癌患者生命质量的影响及其护理经验。方法选取100例中晚期食管鳞癌患者,随机分为治疗组与对照组,每组50例。两组患者均给予多西紫杉醇与顺铂化疗,治疗组在化疗的基础上给予DC-CIK治疗,治疗前及治疗后21d用肿瘤生命质量核心量表(QLQ-C30)进行评估并比较、记录不良反应。结果治疗后,两组QLQC30整体功能、特异性症状模块各个指标及整体生命质量评分均明显优于治疗前,且治疗后治疗组优于对照组(P>0.05)。治疗组治疗中出现发热、寒战,两组患者治疗后均出现不同程度消化道反应、骨髓抑制,且治疗组不良反应发生率低于对照组(P<0.05)。结论 DC-CIK联合化疗能改善中晚期食管鳞癌患者的生命质量。在治疗过程中全面、细致、规范的护理是治疗成功的重要前提。Objective To investigate the effect of DC‐CIK combined with the chemotherapy of cisplatin and docetaxel（DC regimen） on the quality of life in the patients with moderate and advanced esophageal squamous carci‐noma and its nursing experience .Methods 100 cases of moderate and advanced esophageal squamous carcinoma were selected and randomly divided into the treatment group and the control group ,50 cases in each group .The two groups were given the chemotherapy of cisplatin and docetaxel（DC regimen） .On the basis of chemotherapy ,the treatment group was given the DC‐CIK therapy .The evaluation by using QLQ‐C30 was performed before treatment and on 21 d after treatment .The adverse reactions were recorded .Results The scores of various indicators in the allomeric func‐tion ,specific symptom modules of QLQ‐C30 scores and the whole life quality after treatment in the two groups were significantly superior to those before treatment（P〈 0 .05） ,moreover the treatment group after treatment was superi‐or to the control group（P〈 0 .05） .Fever ,chills appeared during therapy in the treatment group ;different degrees of gastrointestinal reactions and bone marrow suppression occurred after treatment in the two groups ,moreover the oc‐currence rates of adverse reactions in the treatment group were lower than those in the control group（P〈 0 .05） .Con‐clusion DC‐CIK combined with chemotherapy can improve the quality of life in the patients with moderate and ad‐vanced esophageal squamous carcinoma .The comprehensive ,meticulous and normalized nursing care during treatment course is the important premise of therapeutic success .

关 键 词：中晚期食管鳞癌 DC-CIK 生命质量 护理 

分 类 号：R735.105[医药卫生—肿瘤]